197784-39-7

Upstream product

• 100-53-8 phenylmethanethiol 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 22900-10-3 (4R,5S)-tetrahydro-2H-pyran-2,4,5-triol 
• 197784-37-5 ethyl [2-deoxy-5-O-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl]acetate 
• 79308-52-4 ethyl 2-[(4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]acetate 
• 79308-40-0 ethyl 2,3,4-trideoxy-D-ribo-hept-2-enoate 
• 130472-43-4 2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-D-ribofuranose 

Relevant academic research and scientific papers

Ethyl[2-deoxy-5-O-(4,4'-dimethoxytrityl)-α-and β-D-erythro- pentofuranosyl] acetates as versatile intermediates in nucleic acid chemistry

The title compounds (1a,b) were synthesized in three steps from 2-deoxy- D-ribose, and used in the preparation of oligonucleotide conjugates, branched oligonucleotides as well as homo-N-nucleosides.

C-glycoside phosphoramidite building block for versatile functionalization of oligodeoxyribonucleotides

A chiral non-nucleosidic phosphoramidite building block containing a thioester function in its structure, 4, is synthesized in six steps starting from '2-deoxy-D-ribose'. It is used in the machine-assisted oligonucleotide synthesis in a conventional manner. Upon completion of the oligonucleotide chain assembly the thioester bond is cleaved with various nucleophiles (hydroxide ion, propane-1,3-diamine, cystamine, histamine), resulting in oligonucleotide conjugates with a tether group in the middle of the oligonucleotide chain.