1304772-10-8

Basic information

• Product Name: 5-(3,4-dichlorobenzyloxy)-1,3-phenylene diacetate
• Synonyms: 5-(3,4-dichlorobenzyloxy)-1,3-phenylene diacetate
• CAS NO: 1304772-10-8
• Molecular Weight: 369.201
• Mol File: 1304772-10-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(3,4-dichlorobenzyloxy)-1,3-phenylene diacetate(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3,4-dichlorobenzyloxy)-1,3-phenylene diacetate(1304772-10-8)
• EPA Substance Registry System: 5-(3,4-dichlorobenzyloxy)-1,3-phenylene diacetate(1304772-10-8)

Safety Data

• Hazardous Substances Data: 1304772-10-8(Hazardous Substances Data)

Upstream product

• 116345-96-1 5-hydroxy-1,3-phenylene diacetate 
• 102-47-6 3,4-Dichlorophenylmethyl chloride 
• 108-73-6 3,5-dihydroxyphenol 

Downstream Products

• 1304772-19-7 5-(3,4-dichlorobenzyloxy)benzene-1,3-diol 

Relevant articles and documents

Synthesis and anti-melanogenic activity of hydroxyphenyl benzyl ether analogues

In order to develop potent skin whitening agents, we have synthesized 17 hydroxyphenyl benzyl ether compounds and tested their melanin synthesis inhibitory activity, DPPH free radical scavenging activity and tyrosinase inhibitory activity. Compounds 32, 35 and 36 possessing 4-hydroxyphenyl benzyl ether structure showed excellent inhibitory capacity with almost 50-fold than arbutin used as a reference in the inhibition test of α-MSH stimulated melanin synthesis in B-16 cells. 4-Hydroxyphenyl benzyl ether compounds also showed good antioxidant activity in the DPPH free radical scavenging test. The tyrosinase function was effectively inhibited by 3,5-dihydroxyphenyl benzyl ether analogues, especially compounds 18, 22, and 24.