1304788-30-4Relevant articles and documents
Synthesis and studies on antidepressant effect of 5,7-Dihydroxyflavanone derivatives
Zhao, Dong-Hai,Sui, Xin,Qu, You-Le,Yang, Li-Ye,Wang, Xian,Guan, Li-Ping
, p. 1129 - 1132 (2011/12/16)
A series of 5,7-dihydroxyflavanone derivatives were synthesized and evaluated their antidepressant activities. The results showed that of nine compounds significantly reduced times during the forced swimming test at a dose of 10 mg/kg, indicative of antidepressant activity. Among the compounds, 4o (4'-methoxy-5,7,3'-trihydroxyflavanone) was found to be the most potent and it was observed that the compound 4o at dose of 10, 20 and 40 mg/kg significantly reduced the duration of immobility times in the Forced swimming test in mice 0.5 h after treatment.