130485-14-2

Upstream product

• 28750-98-3 (benzoyl-methyl-amino)-(4-methoxy-phenyl)-acetic acid 
• 28750-90-5 2-(4-methoxy-phenyl)-3-methyl-5-oxo-4-phenyl-4,5-dihydro-oxazolium betaine 
• 28544-46-9 [(4-methoxy-benzoyl)-methyl-amino]-phenyl-acetic acid 
• 14533-86-9 methyl (E)-2-cyano-3-phenylprop-2-enoate 
• 28609-00-9 4-(4-methoxy-phenyl)-3-methyl-5-oxo-2-phenyl-4,5-dihydro-oxazolium betaine 
• 4891-38-7 phenylpropynoic acid methyl ester 
• 130485-04-0 3-Cyano-5-(4-methoxy-phenyl)-1-methyl-2,4-diphenyl-2,3-dihydro-1H-pyrrole-3-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Regioselectivity in the 1,3-dipolar cycloaddition of muenchnones with two electrophilic alkynes. Attempt of rationalization.

The 1,3-dipolar cycloaddition reaction of several unsymmetrically substituted muenchnones with methyl propiolate 3a and with methyl 3-phenylpropiolate 3b has been examined.The reaction generally proceeds with formation of mixtures of both possible regioisomeric pyrroles.The dipolarophile 3b is more selective than 3a in accordance with the literature.Sustmann's variation-perturbation theory could not account for the observed regioselectivities, this theory gives correct predictions with alkenes as we have shown recently. 1,3-cycloaddition / muenchnones / pyrroles / regioselectivity