1304876-41-2Relevant academic research and scientific papers
Copper-catalyzed one-pot synthesis of 2H-1,4-benzoxazin-3-(4H)-ones from 2-(o-haloaryloxy)acyl chlorides and primary amines
Hu, Qunxian,Xia, Ziming,Fan, Ling,Zheng, Jiening,Wang, Xiaoxia,Lv, Xin
, p. 129 - 142 (2012/05/04)
A facile and efficient Cu(I)-catalyzed one-pot synthesis of 2H-1,4-benzoxazin-3-(4H)-one derivatives has been developed. The condensation between 2-(o-haloaryloxy)acyl chlorides and primary amines followed by Cu(I)-catalyzed intramolecular C-N bond coupling afforded a variety of 2H-1,4-benzoxazin-3-(4H)-ones in good to excellent yields. Diversified substitutents on the 4-position could be conveniently introduced. ARKAT-USA, Inc.
