130498-00-9

Upstream product

• 79-22-1 methyl chloroformate 
• 130497-99-3 (4S,6R,7R)-6,7-di-O-isopropylidene-4-(4-methoxybenzyloxy)oct-1-yne 
• 818-58-6 methyl (E)-pent-3-enoate 
• 111043-63-1 (3R,4R)-3,4-di-O-isopropylidenepentanal 
• 325706-85-2 (3R,4R)-3,4-di-O-isopropylidene-1-tert-butyldimethylsilyloxypentane 
• 935248-67-2 (S)-5-hydroxy-6-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-hex-2-ynoic acid methyl ester 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 
• 824-94-2 p-methoxybenzyl chloride 
• 39161-19-8 pent-3-en-1-ol 
• 80684-00-0 tert-butyl dimethyl(pent-3-en-1-yloxy)silane 
• 111043-64-2 (4S,6R,7R)-6,7-di-O-isopropylideneoct-1-yn-4-ol 
• 325706-76-1 (E)-pent-3-en-1-ol tert-butyldimethylsilyl ether 
• 106987-88-6 2-[(4R,5R)-2,2,5-trimethyl-1,3-dioxolan-4-yl]-1-ethanol 
• 764-37-4 (E)-3-penten-1-ol 

Downstream Products

• 1103775-08-1 C₁₈H₂₄O₆ 
• 325706-80-7 (2E,5R,7R,8R)-3-bromo-1-tert-butyldiphenylsilyloxy-7,8-di-O-isopropylidene-5-(4-methoxybenzyloxy)non-2-ene 
• 325706-83-0 (S)-5-[2-(tert-Butyl-diphenyl-silanyloxy)-eth-(Z)-ylidene]-7-(4-methoxy-benzyloxy)-2,2-dimethyl-1-phenylsulfanyl-8-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-octan-3-ol 
• 325706-75-0 (7S,9R,10R)-5-[(E)-2-tert-butyldiphenylsilyloxyethylidene]-7-(4-methoxybenzyloxy)-2,2-dimethyl-1-phenylsulfanyl-9,10-di-O-isopropylideneundecan-3-one 

Relevant academic research and scientific papers

Syntheses of C17-C27 fragments of 20-deoxybryostatins for assembly using Julia and metathesis reactions

Two approaches to the synthesis of compounds corresponding to the C17-C27 fragment of the 20-deoxybryostatins are described. The first approach is based on the palladium(0) catalysed coupling of tin enolates, generated in situ from enol acetates using tri

Total synthesis of bryostatin 16 using a Pd-catalyzed diyne coupling as macrocyclization method and synthesis of C20-epi-bryostatin 7 as a potent anticancer agent

Asymmetric total synthesis of bryostatin 16 was achieved in 26 steps in the longest linear sequence and in 39 total steps from aldehyde 10. A Pd-catalyzed alkyne-alkyne coupling was employed for the first time as a macrocyclization method in a natural pro

Synthesis of the C(17)-C(27) fragment of the 20-deoxybryostatins

A synthesis of the C(17)-C(27) fragment of the 20-deoxybryostatins is described in which the key step is a palladium(0) catalysed coupling of a tributyltin enolate with a vinylic bromide. (C) 2000 Elsevier Science Ltd.