13050-38-9

Basic information

• Product Name: BENZILIC HYDRAZIDE
• Synonyms: TIMTEC-BB SBB009368;alpha-hydroxy-alpha-phenyl-benzeneaceticacihydrazide;AKOS B014999;2-HYDROXY-2,2-DIPHENYLETHANOHYDRAZIDE;ASISCHEM Z67643;ART-CHEM-BB B014999;BENZILIC HYDRAZIDE;BENZILIC ACID HYDRAZIDE
• CAS NO: 13050-38-9
• Molecular Formula: C₁₄H₁₄N₂O₂
• Molecular Weight: 242.27
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
• Mol File: 13050-38-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 511.6°Cat760mmHg
• Flash Point: 263.2°C
• Appearance: /
• Density: 1.253g/cm³
• Vapor Pressure: 2.74E-11mmHg at 25°C
• Refractive Index: 1.626
• CAS DataBase Reference: BENZILIC HYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: BENZILIC HYDRAZIDE(13050-38-9)
• EPA Substance Registry System: BENZILIC HYDRAZIDE(13050-38-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 13050-38-9(Hazardous Substances Data)

Usage

General Description

Benzilic hydrazide is a chemical compound with the molecular formula C14H14N2O2. It is formed by the reaction of benzil with hydrazine. Benzilic hydrazide is a white crystalline solid that is used as a reagent in organic synthesis, particularly in the preparation of hydrazides, which are important intermediates in the pharmaceutical and agricultural industries. It can also undergo rearrangement to form a diazepine ring, making it a useful precursor in the synthesis of heterocyclic compounds. Benzilic hydrazide has also been studied for its potential as an anti-inflammatory agent and for its ability to inhibit the growth of certain cancer cell lines. Due to its versatile reactivity and potential applications, benzilic hydrazide is a valuable tool in the field of organic chemistry.

InChI:InChI=1/C14H14N2O2/c15-16-13(17)14(18,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10,18H,15H2,(H,16,17)

Upstream product

• 4746-87-6 benzilamide 
• 78486-37-0 benzilic acid salicylidenehydrazide 
• 3469-17-8 2-diazo-1,2-diphenylethan-1-one 
• 525-06-4 diphenyl ketene 
• 79458-07-4 (Diphenylacetyl)(2,4-dioxo-5,5-diphenyl-3-oxazolidinyl)carbamidsaeure-tert-butylester 
• 70165-59-2 (2,4-Dioxo-5,5-diphenyl-3-oxazolidinyl)carbamidsaeure-tert-butylester 
• 108-86-1 bromobenzene 
• 76-89-1 methyl benzilate 
• 84408-70-8 benzilic acid α-propylbenzylidenehydrazide 
• 96973-02-3 diphenylglycolic acid cyclohexylidene hydrazide 
• 79458-12-1 2-(Hydroxydiphenylacetyl)hydrazincarbonsaeure-tert-butylester 
• 52182-15-7 ethyl benzilate 

Downstream Products

• 114302-64-6 benzilic acid-(1-methyl-2-oxo-2-phenyl-ethylidenehydrazide) 
• 86966-85-0 Hydroxy-diphenyl-acetic acid [1-methyl-2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide 
• 86966-79-2 Isatin Z-3-diphenylglycoloylhydrazone 
• 86966-93-0 Hydroxy-diphenyl-acetic acid [5-bromo-2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide 
• 128156-76-3 OTUB₂-COV-10 

Relevant articles and documents

Synthesis and antimycobacterial activity of new 2-hydroxy-N-(3-oxo-1-thia- 4-azaspiro[4.4]non-4-yl)/(3-oxo-1-thia-4-azaspiro[4.5]dec-4-yl)-2, 2-diphenylacetamide derivatives

2-Hydroxy-2,2-diphenylacetohydrazide (2), cyclic ketones, and mercaptoalkanoic acids were converted into 2-hydroxy-N-(3-oxo-1-thia-4- azaspiro[4.4]non/[4.5]dec-4-yl)-2,2-diphenylacetamide derivatives (3, 4) in a one pot procedure. Compounds 3 and 4 were tested for in vitro antimycobacterial activity against M. tuberculosis H37Rv. The compounds were found to provide 0-86% inhibition of mycobacterial growth in the primary screen conducted at 6.25 μg/cm3. Springer-Verlag 2006.

Synthesis and antimicrobial evaluation of new 3-alkyl/aryl-2-[((α, α-diphenyl-α-hydroxy)acetyl)hydrazono]-5-methyl-4-thiazolidinones

New 4-thiazolidinone derivatives of benzilic acid (α,α- diphenyl-α-hydroxyacetic acid) have been synthesized and evaluated for antibacterial and antifungal activities. The reaction of 1- (α,α- diphenyl-α-hydroxy)acetyl-4-alkyl/arylthiosemicarbazides with ethyl 2-bromopropionate gave 3-alkyl/aryl-2-[((α,α-diphenyl-α- hydroxy)acetyl)hydrazono]-5-methyl-4-thiazolidinone derivatives. Their antibacterial and antifungal activities were evaluated against S. aureus ATCC 29213, P. aeruginosa ATCC 27853, E. coli ATCC 25922, C. albicans ATCC 10231, C. parapsilosis ATCC 22019, C. krusei ATCC 6258, T. mentagrophytes var. erinacei NCPF 375, M. gypseum NCPF 580 and T. tonsurans NCPF 245. 3e, 3f, 3g and 3h showed the highest antibacterial activity. Particularly 3a and 3e showed the highest antifungal activities against C. parapsilosis ATCC 22019, T. tonsurans NCPF 245 and M. gypseum NCPF 580.

AMINOACYL DERIVATIVES OF DIARYLGLYCOLIC ACID HYDRAZIDES AND THEIR ANALGESIC ACTIVITY

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