1305118-48-2Relevant academic research and scientific papers
A concise approach towards the synthesis of WS75624 a and WS75624 B via the cross-metathesis of vinyl-functionalized thiazoles
Dash, Jyotirmayee,Melillo, Bruno,Arseniyadis, Stellios,Cossy, Janine
, p. 2246 - 2249 (2011)
Synthetic approach towards precursors of WS75624 A and WS75624 B, two potent endothelin converting enzyme (ECE) inhibitors and potential antihypertensive agents, is reported featuring a key cross-metathesis between a vinyl-functionalized thiazole and a terminal olefin. As the two natural products only differ by the nature of their hydroxyalkyl side-chain, our convergent strategy enable the synthesis of key intermediates of both molecules in a limited amount of steps.
