1305197-31-2

Basic information

• Product Name: 3-(1-benzoyl-piperidin-4-yl)-N-hydroxy-propionamide
• Synonyms: 3-(1-benzoyl-piperidin-4-yl)-N-hydroxy-propionamide
• CAS NO: 1305197-31-2
• Molecular Weight: 276.335
• Mol File: 1305197-31-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(1-benzoyl-piperidin-4-yl)-N-hydroxy-propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1-benzoyl-piperidin-4-yl)-N-hydroxy-propionamide(1305197-31-2)
• EPA Substance Registry System: 3-(1-benzoyl-piperidin-4-yl)-N-hydroxy-propionamide(1305197-31-2)

Safety Data

• Hazardous Substances Data: 1305197-31-2(Hazardous Substances Data)

Upstream product

• 162504-86-1 t-butyl 4-(3-ethoxy-3-oxoprop-1-enyl)-tetrahydropyridine-1(2H)-carboxylate 
• 301232-45-1 tert-butyl 4-(3-ethoxy-3-oxopropyl)-1-piperidinecarboxylate 
• 137076-22-3 tert butyl 4-formylpiperidine-1-carboxylate 
• 123855-51-6 tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate 
• 51144-70-8 ethyl 3-(1-benzoylpiperidin-4-yl)propanoate 

Relevant articles and documents

Alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors

We report here the strategy used in our research group to find a new class of histone deacetylase (HDAC) inhibitors. A series of N-substituted 4-alkylpiperazine and 4-alkylpiperidine hydroxamic acids, corresponding to the basic structure of HDAC inhibitors (zinc binding moiety-linker-capping group) has been designed, prepared, and tested for HDAC inhibition. Linker length and aromatic capping group connection were systematically varied to find the optimal geometric parameters. A new series of submicromolar inhibitors was thus identified, which showed antiproliferative activity on HCT-116 colon carcinoma cells.