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Usage

Uses

Used in Pharmaceutical Industry:
1-(4-Chloro-5-(4-(trifluoromethyl)phenyl)thiophen-2-yl)ethan-1-one is used as an intermediate in the synthesis of pharmaceuticals for its potential anti-inflammatory and anticancer properties. Its unique structure allows it to be a promising candidate in the development of new drugs targeting various health conditions.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(4-Chloro-5-(4-(trifluoromethyl)phenyl)thiophen-2-yl)ethan-1-one is utilized as a building block in the creation of compounds that can be used in the development of pesticides and other agricultural chemicals, contributing to enhanced crop protection and yield.
Used in Optical and Electronic Device Manufacturing:
1-(4-Chloro-5-(4-(trifluoromethyl)phenyl)thiophen-2-yl)ethan-1-one is also used in the production of materials for optical and electronic devices, taking advantage of its chemical and physical properties that can be tailored for specific applications in these industries.
Used in Research and Development Laboratories:
1-(4-Chloro-5-(4-(trifluoromethyl)phenyl)thiophen-2-yl)ethan-1-one can be found in research and development laboratories where scientists study its properties and potential applications in various fields, including the synthesis of novel organic compounds and the exploration of its biological activities.

Upstream product

• 402-43-7 p-trifluoromethylphenyl bromide 
• 34730-20-6 1-(4-chlorothiophen-2-yl)ethan-1-one 

Relevant academic research and scientific papers

Solvent-free palladium-catalyzed direct arylation of heteroaromatics with aryl bromides

Solvent is one of the major sources of waste in the course of catalyzed direct arylations. Some palladium-catalyzed direct arylations of heteroaromatics can be advantageously performed without any solvent. In the presence of palladium catalysts (1 mol%) and potassium acetate as the base, the direct 5-arylation of some thiazoles, thiophenes, furans, or pyrroles with aryl bromides as coupling partners proceeds highly regioselectively and in moderate to high yields. However, the use of these solvent-free conditions is limited to electron-deficient aryl bromides. Copyright

Palladium-catalyzed direct 5-arylation of formyl- or acetyl-halothiophene derivatives

Pd(OAc)2 was found to catalyze the direct arylation of some functionalized halothiophene derivatives allowing the synthesis in only one step of polyfunctionalized arylated thiophenes. In the presence of 2-acetyl-3-chlorothiophene, 2-acetyl-4-chlorothiophene, 2-acetyl-3- bromothiophene diethylacetal or 2-(4-bromothiophen-2-yl)-[1,3]dioxolane, and a variety of aryl bromides, the 5-arylation products were obtained in moderate to high yields employing only 0.5 mol% catalyst. On the other hand, the use of 2-formyl-3-chlorothiophene, 2-acetyl-3-bromothiophene or 2-formyl-3- bromothiophene gave disappointing results.

Cyclopentyl methyl ether: An alternative solvent for palladium-catalyzed direct arylation of heteroaromatics

Some ethers, such as cyclopentyl methyl ether and di-n-butyl ether, which can be considered as "greener" solvents than N,N-dimethylacetamide (DMAc) or DMF, can be advantageously employed for the palladium-catalyzed direct arylation of heteroaromatics. In the presence of such ethers and only 0.5-1 mol% of palladium catalysts at 125-150°C, the direct 5-arylation of thiazoles, thiophenes, or furans by using aryl bromides as coupling partners proceeds in moderate to high yields.