1305253-07-9Relevant academic research and scientific papers
Cyclopentyl methyl ether: An alternative solvent for palladium-catalyzed direct arylation of heteroaromatics
Beydoun, Kassem,Doucet, Henri
experimental part, p. 526 - 534 (2012/03/09)
Some ethers, such as cyclopentyl methyl ether and di-n-butyl ether, which can be considered as "greener" solvents than N,N-dimethylacetamide (DMAc) or DMF, can be advantageously employed for the palladium-catalyzed direct arylation of heteroaromatics. In the presence of such ethers and only 0.5-1 mol% of palladium catalysts at 125-150°C, the direct 5-arylation of thiazoles, thiophenes, or furans by using aryl bromides as coupling partners proceeds in moderate to high yields.
