1305287-91-5Relevant articles and documents
A facile synthesis of multigram quantity of ethyl 3-ethylmorpholine-3- carboxylate
Jagodzinski, Jacek J.,Aubele, Danielle L.,Quincy, David A.,Dappen, Michael S.,Latimer, Lee H.,Hom, Roy K.,Galemmo Jr., Robert A.,Konradi, Andrei W.,Sham, Hing L.
, p. 2471 - 2472 (2011)
A five-step synthesis of ethyl 3-ethylmorpholine-3-carboxylate proceeding from readily available 2-aminobutyric acid is detailed herein.
Selective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce α-synuclein phosphorylation in rat brain
Aubele, Danielle L.,Hom, Roy K.,Adler, Marc,Galemmo, Robert A.,Bowers, Simeon,Truong, Anh P.,Pan, Hu,Beroza, Paul,Neitz, R. Jeffrey,Yao, Nanhua,Lin, May,Tonn, George,Zhang, Heather,Bova, Michael P.,Ren, Zhao,Tam, Danny,Ruslim, Lany,Baker, Jeanne,Diep, Linnea,Fitzgerald, Kent,Hoffman, Jennifer,Motter, Ruth,Fauss, Donald,Tanaka, Pearl,Dappen, Michael,Jagodzinski, Jacek,Chan, Wayman,Konradi, Andrei W.,Latimer, Lee,Zhu, Yong L.,Sham, Hing L.,Anderson, John P.,Bergeron, Marcelle,Artis, Dean R.
supporting information, p. 1295 - 1313 (2013/08/23)
Polo-like kinase-2 (Plk-2) has been implicated as the dominant kinase involved in the phosphorylation of α-synuclein in Lewy bodies, which are one of the hallmarks of Parkinson's disease neuropathology. Potent, selective, brain-penetrant inhibitors of Plk
