1305317-52-5

Basic information

• Product Name: C₃₅H₄₈BIN₄O₁₂
• Synonyms: C₃₅H₄₈BIN₄O₁₂
• CAS NO: 1305317-52-5
• Molecular Weight: 854.501
• Mol File: 1305317-52-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₃₅H₄₈BIN₄O₁₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₅H₄₈BIN₄O₁₂(1305317-52-5)
• EPA Substance Registry System: C₃₅H₄₈BIN₄O₁₂(1305317-52-5)

Safety Data

• Hazardous Substances Data: 1305317-52-5(Hazardous Substances Data)

Upstream product

• 1086703-05-0 (S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(4-hydroxy-3-iodophenyl)acetic acid 
• 1253795-07-1 (S)-2-(tert-butoxycarbonylamino)-3-(4-hydroxy-3-iodo-5-nitrophenyl)propanoic acid 
• 1253795-12-8 (S)-methyl 2-(tert-butoxycarbonylamino)-3-(3-iodo-4-methoxy-5-nitrophenyl)propanoate 
• 1305317-48-9 C₁₁H₁₃IN₂O₅ 
• 1305317-51-4 C₂₄H₃₇BN₂O₈ 
• 1305317-49-0 C₂₅H₃₁IN₂O₆ 
• 621-44-3 3-nitro-L-tyrosine 
• 5575-03-1 (2S)-2-tert-butoxycarbonylamino-3-(4-hydroxy-3-nitro-phenyl)-propionic acid 
• 1305317-50-3 C₃₁H₄₃BN₂O₈ 
• 73183-34-3 bis(pinacol)diborane 

Relevant articles and documents

Broad spectrum antibiotic arylomycin analogs

Arylomycin analogs are provided, wherein the analogs can have broad spectrum bioactivity. Resistance to the antibiotic bioactivity of natural product arylomycin in a range of pathogenic bacterial species has been found to depend upon single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases), wherein the presence of a proline residue confers arylomycin resistance. Arylomycin analogs are provided herein that can overcome that resistance and provide for a broader spectrum of antibiotic bioactivity than can natural product arylomycins such as arylomycin A2. Methods for determining if a bacterial strain is susceptible to narrow spectrum arylomycin antibiotics, or if a broad spectrum analog is required for treatment, is provided. Pharmaceutical compositions and methods of treatment of bacterial infections, and methods of synthesis of arylomycin analogs, are provided.