130532-92-2Relevant academic research and scientific papers
Pyridinium N-2′-pyridylaminide: radical cyclization for the synthesis of benzonaphthyridine derivatives
Nú?ez, Araceli,Sánchez, Aránzazu,Burgos, Carolina,Alvarez-Builla, Julio
, p. 6774 - 6783 (2008/02/07)
The synthesis of benzonaphthyridine derivatives that incorporate a 2-aminopyridine moiety can be performed by intramolecular radical pyridylation of the appropriate substrates, obtained from pyridinium N-2′-pyridylaminide, using TTMSS and AIBN.
Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 2: (3-substituted-5-halo-2-pyridinyl)guanidines
Barber, Christopher G.,Dickinson, Roger P.
, p. 185 - 187 (2007/10/03)
Based on previous modeling predictions, a series of (3-substituted-5-chloro-2-pyridinyl)guanidines have been designed with good potency and selectivity for urokinase-type plasminogen activator (uPA). Compound 36 has a Ki of 0.17 μM and greater than 300-fold selectivity with respect to tPA and plasmin.
REACTIONS OF β-BROMO-N-HETEROAROMATICS WITH PHENYLACETONITRILE
Ohba, Setsuya,Sakamoto, Takao,Yamanaka, Hiroshi
, p. 1301 - 1308 (2007/10/02)
The reaction of 3-bromopyridine with phenylacetonitrile in the presence of NaH in THF gave a simple substitution product, α-phenyl-3-pyridineacetonitrile, whereas the reaction of 5-bromopyrimidine with phenylacetonitrile under similar conditions gave a ring-transformation product, 2-amino-5-bromo-3-phenylpyridine. 3-Bromoquinoline and 4-bromoisoquinoline underwent the former type reaction, while 3-bromo- and 3-chloroisoquinolines were converted into 2-amino-3-phenyl-1-naphthalenecarbonitrile according to the latter type reaction.
