130533-07-2Relevant academic research and scientific papers
Design and synthesis of novel type VI-like β-turn mimetics. Diversity at the i+1 and the i+2 position
De Borggraeve, Wim M.,Verbist, Bie M.P.,Rombouts, Frederik J.R.,Pawar, Vijaykumar G.,Smets, Wim J.,Kamoune, Laila,Alen, Jo,Van Der Eycken, Erik V.,Compernolle, Frans,Hoornaert, Georges J.
, p. 11597 - 11612 (2007/10/03)
In this paper, a synthetic approach for functionalised 5-aminopiperidinone- 2-carboxylate (APC) systems as non-pro cis-peptide bond containing external β-turn mimics is presented. The scope and limitations of the synthetic method are discussed and the pot
Decyanation of 2-Oxoazetidine-4-carbonitriles as a New Route to (4S)-4--azetidin-2-one, an Intermediate for the Synthesis of 1β-Methylcarbapenem Antibiotics
Shirai, Masashi,Nishiwaki, Tarozaemon
, p. 2018 - 2031 (2007/10/02)
Base-catalysed cyclisation of the α-bromoacetamides derived from aminonitriles gave 4-alkyl- and 4-aryl-2-oxoazetidine-4-carbonitriles in high yield, whose cyano group was removed with sodium in liquid ammonia. (3R)-2-(4-Methoxybenzylamino)-3-benzyloxy-me
