1305339-37-0

Basic information

• Product Name: C₂₂H₂₈O₃Si
• Synonyms: C₂₂H₂₈O₃Si
• CAS NO: 1305339-37-0
• Molecular Weight: 368.548
• Mol File: 1305339-37-0.mol

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₈O₃Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₈O₃Si(1305339-37-0)
• EPA Substance Registry System: C₂₂H₂₈O₃Si(1305339-37-0)

Safety Data

• Hazardous Substances Data: 1305339-37-0(Hazardous Substances Data)

Upstream product

• 88159-06-2 tert-butyl(diphenyl)(2-propynyloxy)silane 
• 1305339-36-9 C₂₂H₂₆OSi 

Downstream Products

• 1305339-35-8 C₂₅H₃₂O₃Si 

Relevant articles and documents

Enantioselective formal total synthesis of the Dendrobatidae frog toxin, (+)-pumiliotoxin B, via O-directed alkyne free radical hydrostannation

Herein we describe our application of the O-directed free radical hydrostannation of disubstituted alkylacetylenes (with Ph3SnH and Et3B) to the (+)-pumiliotoxin B total synthesis problem. Specifically, we report on the use of this method in the synthesis of the Overman alkyne 8, and thereby demonstrate the great utility of this process in a complex natural product total synthesis setting for the very first time. We also report here on a new, stereocontrolled, and highly practical enantioselective pathway to Overman's pyrrolidine epoxide partner 9 for 8, which overcomes the previous requirement for use of preparative HPLC to separate the 1:1 mixture of diastereomeric epoxides that was obtained in the original synthesis of 9.