1305347-83-4Relevant academic research and scientific papers
Enantioconvergent alkylation of ketones with racemic secondary alcohols: Via hydrogen borrowing catalysis
Cheang, Daniella M. J.,Armstrong, Roly J.,Akhtar, Wasim M.,Donohoe, Timothy J.
, p. 3543 - 3546 (2020/04/03)
An enantioconvergent method for the alkylation of o-disubstituted aryl ketones with racemic secondary alcohols is described. This process is mediated by a commercially available iridium catalyst and proceeds via hydrogen borrowing catalysis. The highly enantioenriched β-substituted ketone products were readily cleaved to a wide range of functional groups via retro-Friedel-Crafts acylation.
Influence of geminal disubstitution on samarium diiodide induced reductive cyclizations of γ-aryl ketones
Niermann, André,Reissig, Hans-Ulrich
experimental part, p. 525 - 528 (2011/05/02)
Geminal disubstitution at the alkyl chain of γ-aryl ketones significantly influences the efficacy of samarium diiodide induced cyclizations providing significantly higher yields. β,β-Disubstituted aryl ketones 11a-e and γ,γ-disubstituted aryl ketone 14 could be converted into the corresponding hexahydronaphthalene derivatives in good yields. On the other hand, α,α-disubstituted ketone 9 only gave the secondary alcohol 10 along with recovered starting material. Aryl ketones containing substituents with hetero-atoms could also be cyclized in high yields and substrates such as 11d with sterically demanding cyclic substituents efficiently afforded spiro compounds. Georg Thieme Verlag Stuttgart.
