130539-62-7

Upstream product

• 1042397-90-9 2,3,4-tri-O-benzyl-1-deoxy-1-thio-α-D-glucopyranose 
• 108-24-7 acetic anhydride 

Downstream Products

• 1393083-67-4 6-O-acetyl-2,3,4,2′,3′,4′,6′-hepta-O-benzyl-1-thio-α,α-D-trehalose 
• 1393083-66-3 6-O-acetyl-2,3,4-tri-O-benzyl-1-deoxy-1-thio-α-D-glucopyranose 

Relevant academic research and scientific papers

A facile and highly stereoselective synthesis of 1-thiotrehalose

A facile and highly stereoselective synthesis of 1-thiotrehalose, that is, α,α-S-linked trehalose, is described. Glycosylation of configurationally pure α-glucosyl thiol 5 with glucosyl trichloroacetimidate 6 or glucosyl thioimidate 9 followed by deprotection afforded 1-thiotrehalose in excellent α-stereoselectivity and high yield. A different synthetic route to the key building block, α-glucosyl thiol 5, was also investigated in this report.