13058-77-0

Usage

Uses

Used in Pharmaceutical Industry:
8-CHLORO-[1,7]NAPHTHYRIDINE is used as a building block for the synthesis of various pharmaceutical compounds, particularly for the development of anti-bacterial and anti-cancer agents. The presence of the chloro group in the compound can enhance its chemical and biological properties, making it a promising candidate for drug discovery and development.
Used in Materials Science:
8-CHLORO-[1,7]NAPHTHYRIDINE has been studied for its potential applications in materials science, where its unique properties can contribute to the development of new materials with specific characteristics.
Used in Biological Imaging:
8-CHLORO-[1,7]NAPHTHYRIDINE is also considered as a fluorescent probe in biological imaging, where its properties can be utilized for visualizing and studying biological processes and structures.

InChI:InChI=1/C8H5ClN2/c9-8-7-6(3-5-11-8)2-1-4-10-7/h1-5H

Upstream product

• 67967-11-7 1,7-naphthyridinyl-8(7H)-one 
• 452-58-4 2,3-Diaminopyridine 
• 67967-11-7 8-hydroxy-1,7-naphthyridine 
• 17965-82-1 8-amino-1,7-naphthyridine 

Relevant academic research and scientific papers

Preparation method of formaldehyde-substituted aza-condensed ring compound

The invention provides a preparation method of a formaldehyde-substituted aza-condensed ring compound, comprising the following steps: by using an aza-condensed ring lactam compound as a starting material, carrying out halogenation reaction, methylation reaction and methyl oxidation reaction to obtain the formaldehyde-substituted aza-condensed ring compound. According to the preparation method ofthe formaldehyde-substituted aza-condensed ring compound, the whole synthesis route is good in step repeatability, mild in operation condition and high in safety, and large-scale production and industrial popularization are facilitated; post-treatment energy consumption is low, a large amount of toxic wastewater is not generated, no pollution is caused to the environment, the production safety level and the production cost are reduced, application of green and environment-friendly industrial production is facilitated, and wide application prospects are achieved.

HETEROARYL COMPOUNDS AS CXCR4 INHIBITORS, COMPOSITION AND METHOD USING THE SAME

The present disclosure provides heteroaryl compounds of Formula (I), processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from or related to the CXCR4 pathway.

1-SUBSTITUTED 1,2,3,4-TETRAHYDRO-1,7-NAPHTHYRIDIN-8-AMINE DERIVATIVES AND THEIR USE AS EP4 RECEPTOR ANTAGONISTS

The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof has an EP4 receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of EP4 receptor associated diseases (e.g., rheumatoid arthritis, aortic aneurysm (e.g. abdominal aortic aneurysm, thoracic aortic aneurysm, thoracoabdominal aortic aneurysm etc.), endometriosis, ankylosing spondylitis, inflammatory breast cancer etc.) and the like.