8-CHLORO-[1,7]NAPHTHYRIDINE

Base Information

• Chemical Name: 8-CHLORO-[1,7]NAPHTHYRIDINE
• CAS No.: 13058-77-0
• Molecular Formula: C8H5ClN2
• Molecular Weight: 164.594
• Hs Code.: 2933990090
• Mol file: 13058-77-0.mol

Synonyms:8-CHLORO-[1,7]NAPHTHYRIDINE

Chemical Property of 8-CHLORO-[1,7]NAPHTHYRIDINE

Chemical Property:

• Vapor Pressure: 0.00128mmHg at 25°C
• Refractive Index: 1.662
• Boiling Point: 307.9 °C at 760 mmHg
• PKA: 1.54±0.30(Predicted)
• Flash Point: 168.8 °C
• PSA: 25.78000
• Density: 1.349g/cm³
• LogP: 2.28320

Purity/Quality:

98%min ^*data from raw suppliers

8-Chloro-1,7-Naphthyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-CHLORO-[1,7]NAPHTHYRIDINE

There total 5 articles about 8-CHLORO-[1,7]NAPHTHYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

8-hydroxy-1,7-naphthyridine (67967-11-7) → 8-chloro-[1,7]naphthyridine (13058-77-0)

Guidance literature:

With trichlorophosphate; at 100 ℃; for 16h;

Reference yield: 26.0%

8-amino-1,7-naphthyridine (17965-82-1) → 8-chloro-[1,7]naphthyridine (13058-77-0)

Guidance literature:

With hydrogenchloride; copper(l) chloride; sodium nitrite; In water; at 20 ℃; for 3h;

Reference yield:

1,7-naphthyridinyl-8(7H)-one (67967-11-7) → 8-chloro-[1,7]naphthyridine (13058-77-0)

Guidance literature:

With trichlorophosphate; at 100 ℃; for 2h;

upstream raw materials:

8-amino-1,7-naphthyridine

8-hydroxy-1,7-naphthyridine

2,3-Diaminopyridine

1,7-naphthyridinyl-8(7H)-one

Refernces

• 1、 -. "Preparation method of formaldehyde-substituted aza-condensed ring compound". Paragraph 0133-0135. . Retrieved 2020/06/02.
• 2、 -. "1-SUBSTITUTED 1,2,3,4-TETRAHYDRO-1,7-NAPHTHYRIDIN-8-AMINE DERIVATIVES AND THEIR USE AS EP4 RECEPTOR ANTAGONISTS". . . Retrieved 2017/02/09.