13060-72-5Relevant articles and documents
Palladium meditated CPhenyl-H bond activation of 2-furylimines versus tert-2-furylbenzylamines
Hu, Zhao-Xia,Ma, Nan,Zhang, Jin-Hua,Hu, Wen-Ping,Wang, Hong-Xing
, p. 30 - 35 (2014)
The reactions of 2-furylimines 2a-f and Na2PdCl4 in the presence of NaOAc at 8-10°C result in nitrogen-palladium coordinated complexes 3a-f. Reduction of 2d-f with NaBH4 followed by N-methylation leads to the corresponding tert-2-furylbenzylamines 5a-c. Treatment of 5a-c with Na2PdCl4 at the same reaction condition as mentioned above affords palladacycles 6a-c where the Pd atoms connect to the phenyl ring rather than the furyl ring. The fact that 5a-c are more active than 2d-f in CPhenyl-H bond activation implies that the electron density of C10 or C8 atom in former is higher than those in latter. Compounds 3a-f, 5a-c, 6a-c were identified by elemental analysis, IR and NMR. In addition, the structures of 3b, 3f and 6c were also confirmed by their single crystal X-ray diffractions.
Rational Design of Cobalt-Platinum Alloy Decorated Cobalt Nanoparticles for One-Pot Synthesis of Imines from Nitroarenes and Aldehydes
Gong, Wanbing,Han, Miaomiao,Chen, Chun,Lin, Yue,Wang, Guozhong,Zhang, Haimin,Zhao, Huijun
, p. 5948 - 5958 (2020/10/02)
Developing high-performance heterogeneous catalysts for one-pot reductive amination reactions is critically important for pharmaceutical and agrochemical synthetic industries. In this work, N-doped carbon nanotubes supported CoPt alloy decorated Co nanoparticles (NPs) are successfully fabricated. As a consequence, the resultant catalyst exhibits desirable activity, selectivity and stability toward the one-pot synthesis of imines. More importantly, the extensive experimental studies and density function theory (DFT) calculations results reveal that the high catalytic activity of the catalyst is mainly due to the co-existence of CoPt alloy NPs and Co NPs with Co?Nx active sites. The high selectivity of imines could be ascribed to the following aspects: (1) competitively preferred adsorption of nitroarenes to avoid side-hydrogenation of aldehydes; (2) weakened adsorption of imines to minimize its over-hydrogenation. This work may provide a promising direction and strategy to design high-performance reductive amination catalysts for industrial applications.
Dimethyl (2-Furyl)-N-(2-Methoxyphenyl)Aminomethylphosphonate Induces Apoptosis in Esophageal Squamous Cancer Cells. Structure Versus Activity of its Selected Analogs
Klimczak, Anna Agnieszka,Matusiak, Agnieszka,Lewkowski, Jaroslaw,Bitner, Jan,Szemraj, Janusz,Kontek, Renata
, p. 1088 - 1099 (2015/08/04)
Cytotoxicities of several new aminophosphonic compounds bearing 2-furyl moiety 2b-d and 3a-c on KYSE 30, 150, and 270 esophageal cancer cell lines are reported here. The qualitative study on correlations between the structure and cytotoxic activity of fur
