130618-96-1

Upstream product

• 1247869-24-4 2-(6-(4-(2-methoxyphenyl)piperazin-1-yl)hexyl)isoindoline-1,3-dione 
• 629-03-8 1 ,6-dibromohexane 
• 24566-79-8 2-(6-bromohexyl)isoindole-1,3-dione 

Downstream Products

• 96671-26-0 6-chloro-2-methyl-1,1-dioxo-7-sulfamoyl-1,2,3,4-tetrahydro-1λ⁶-benzo[1,2,4]thiadiazine-3-carboxylic acid 6-[4-(2-methoxy-phenyl)-piperazin-1-yl]-hexylamide 
• 1247869-23-3 C₂₇H₃₅N₃O₃S 
• 1247869-22-2 C₂₈H₃₅N₃O₂ 
• 827597-07-9 N-[4-(6-aminohexyl)-1-(2-methoxyphenyl)piperazine]-2-(diphenylphosphanyl)benzylamine 

Relevant academic research and scientific papers

Design and synthesis of new potent 5-HT7 receptor ligands as a candidate for the treatment of central nervous system diseases

Owing to their multifunctional pharmacological profiles (including dual 5-HT1A/5-HT7 action), arylpiperazine derivatives are widely used for treating central nervous system diseases including the depression or neuropathic pain. Herein we describe the design, synthesis and evaluation of biological activity of novel 5-HT7 ligands derived of 2,4,6-triamino-1,3,5-triazine. The studied compounds showed affinity and high selectively towards 5-HT7 receptor with the two most active compounds 34 (Ki = 61 nM), 22 (Ki = 109 nM) showing good metabolic stability and moderate affinity to CYP3A4 isoenzyme. Compound 22 had high hepatotoxicity at a concentration below 50 μM, while compound 34 showed low hepatotoxicity even at a concentration above 50 μM.

Synthesis and in vitro binding studies of piperazine-alkyl-naphthamides: Impact of homology and sulphonamide/carboxamide bioisosteric replacement on the affinity for 5-HT1A, α2A, D4.2, D3 and D2L receptors

A series of carboxamide and sulphonamide alkyl(ethyl to hexyl)piperazine analogues were prepared and tested for their affinity to bind to a range of receptors potentially involved in psychiatric disorders. These chemical modifications led us to explore th