130620-41-6Relevant academic research and scientific papers
Some synthetic approaches to glutamate AMPA receptor agonists based on isoxazolones
Cox, Matthew,Jahangiri, Saba,Perkins, Michael V.,Prager, Rolf H.
, p. 685 - 688 (2007/10/03)
Several approaches to the synthesis of derivatives of the antifungal antibiotic TAN-950A, which is also an agonist of glutamate at hippocampal neurons, are reported. Additions of isoxazolon-4-yl anions to methyleneoxazolidinones were not useful because ad
Synthesis and biological activity of (S)-2-amino-3-(2,5-dihydro-5-oxo-4-isoxazolyl)propanoic acid (TAN-950 A) derivatives
Tamura,Matsushita,Iwama,Harada,Kishimoto,Itoh
, p. 1199 - 1212 (2007/10/02)
(S)-2-Amino-3-(2,5-dihydro-5-oxo-4-isoxazolyl)propanoic acid (TAN-950 A (1)) is a novel amino acid antibiotic which shows a high affinity for glutamate receptors of the central nervous system. To improve the affinity for glutamate receptors, the structure
