130620-52-9

Upstream product

• 130621-90-8 (S)-4-(Hydroxy-phenyl-methyl)-5-oxo-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 100-52-7 benzaldehyde 
• 128811-48-3 1‐(tert‐butyl) 2‐methyl (R)‐5‐oxopyrrolidine‐1,2‐dicarboxylate 
• 98-88-4 benzoyl chloride 
• 108963-96-8 (S)-1-tert-butoxycarbonyl-5-methoxycarbonyl-pyrrolidin-2-one 

Downstream Products

• 130620-41-6 methyl (S)-2-tert-butoxycarbonylamino-3-(2,5-dihydro-5-oxo-3-phenyl-4-isoxazolyl)propanoate 

Relevant academic research and scientific papers

Some synthetic approaches to glutamate AMPA receptor agonists based on isoxazolones

Several approaches to the synthesis of derivatives of the antifungal antibiotic TAN-950A, which is also an agonist of glutamate at hippocampal neurons, are reported. Additions of isoxazolon-4-yl anions to methyleneoxazolidinones were not useful because ad

Synthesis and biological activity of (S)-2-amino-3-(2,5-dihydro-5-oxo-4-isoxazolyl)propanoic acid (TAN-950 A) derivatives

(S)-2-Amino-3-(2,5-dihydro-5-oxo-4-isoxazolyl)propanoic acid (TAN-950 A (1)) is a novel amino acid antibiotic which shows a high affinity for glutamate receptors of the central nervous system. To improve the affinity for glutamate receptors, the structure