13036-57-2

Basic information

• Product Name: 2-Chloro-4-methylpyrimidine
• Synonyms: 2-CHLORO-4-METHYLPYRIMIDINE;Pyrimidine, 2-chloro-4-methyl- (6CI,7CI,8CI,9CI);2-CHLORO-4-METHYLPYRIMIDINE 98%;2-Chloro-6-methylpyrimidine;2-Chloro-4-methyl-1,3-diazine;chloro-4-MethylpyriMidine
• CAS NO: 13036-57-2
• Molecular Formula: C₅H₅ClN₂
• Molecular Weight: 128.56
• Product Categories: PYRIMIDINE;pharmacetical;Nucleotides and Nucleosides;pyridine;Bases & Related Reagents;Nucleotides;Halides;Pyrazines, Pyrimidines & Pyridazines;Boronic Acid;Chlorinated heterocyclic series;Aromatics;Heterocycles;Miscellaneous Reagents;Building Blocks;C4 to C5;Chemical Synthesis;Heterocyclic Building Blocks;New Products for Chemical Synthesis;Pyrimidines;Heterocycle-Pyrimidine series
• Mol File: 13036-57-2.mol
• Article Data: 28

Chemical Properties

• Melting Point: 35-36°C
• Boiling Point: 94°C/17mmHg(lit.)
• Flash Point: 98℃
• Appearance: pale yellow solid
• Density: 1.235 g/cm³
• Vapor Pressure: 0.209mmHg at 25°C
• Refractive Index: 1.53
• Storage Temp.: Keep Cold/Store under Nitrogen
• Solubility: Chloroform
• PKA: -0.93±0.20(Predicted)
• Sensitive: Moisture Sensitive
• Stability: Toxic
• CAS DataBase Reference: 2-Chloro-4-methylpyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-methylpyrimidine(13036-57-2)
• EPA Substance Registry System: 2-Chloro-4-methylpyrimidine(13036-57-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-41-37/38
• Safety Statements: 26-39
• WGK Germany: 3
• TSCA: N
• HazardClass: IRRITANT
• Hazardous Substances Data: 13036-57-2(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

Uses

2-Chloro-4-methylpyrimidine (cas# 13036-57-2) is a compound useful in organic synthesis.

InChI:InChI=1/C5H5ClN2/c1-4-2-3-7-5(6)8-4/h2-3H,1H3

Upstream product

• 5424-21-5 2,4-dichloro-6-methylpyrimidine 
• 5348-51-6 2-hydroxy-4-methylpyrimidine hydrochloride 
• 1722-12-9 2-chloropyrimidine 
• 917-54-4 methyllithium 
• 3934-20-1 2,6-Dichloropyrimidine 
• 75-24-1 trimethylaluminum 
• 1134-81-2 1-benzyl-3,5-dimethyl-1H-pyrazole 
• 67-66-3 chloroform 
• 15231-48-8 2-hydroxy-4-methylpyrimidine 
• 84-58-2 2,3-dicyano-5,6-dichloro-p-benzoquinone 
• 944902-31-2 2-chloro-4-pyrimidinylmethyl chloride 
• 13061-96-6 dihydroxy-methyl-borane 
• 108-52-1 4-Methyl-pyrimidin-2-ylamin 
• 676-58-4 methylmagnesium chloride 

Downstream Products

• 17758-42-8 2-ethoxy-4-methylpyrimidine 
• 874495-07-5 4-(4-methyl-pyrimidin-2-yloxy)-benzenesulfonic acid amide 
• 684283-62-3 4-hydroxy-benzenesulfonic acid-(4-methyl-pyrimidin-2-ylamide) 
• 116028-84-3 N'-benzyl-N,N-dimethyl-N'-(4-methyl-pyrimidin-2-yl)-ethane-1,2-diamine 
• 14001-60-6 2-methoxy-4-methylpyrimidine 
• 860431-09-0 N-(4-methyl-pyrimidin-2-yl)-sulfanilic acid amide 
• 127-79-7 sulfamerazina 
• 53112-26-8 4-methyl-N-phenylpyrimidin-2-amine 
• 25710-14-9 N-benzyl-(4-methylpyrimidin-2-yl)amine 
• 127-73-1 N-[4-(4-Methyl-pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide 
• 78430-30-5 4-methyl-2-phenoxy-pyrimidine 
• 3438-46-8 4-Methylpyrimidine 
• 77768-02-6 2-Cyan-4-methylpyrimidin 
• 63170-77-4 2-hydrazinyl-4-methylpyrimidine 

Relevant articles and documents

Redox deracemization of phosphonate-substituted dihydropyrimidines

An efficient redox deracemization of the phosphonic ester substituted 3,4-dihydropyrimidin-2-one (DHPM) derivatives is described. The one-pot deracemization strategy consisted of the oxidization to destroy the stereocenter center and the following asymmetric transfer hydrogenation to regenerate the chiral carbon center with the vicinal phosphonic ester group, providing a series of optically active phosphonate substituted DHPMs with up to 96% ee.

Continuous synthesis method of 2-chloropyrimidine-4-formic acid compound

The invention provides a continuous synthesis method of a 2-chloropyrimidine-4-formic acid compound. The 2-chloropyrimidine-4-formic acid compound has a structure represented by a formula I, wherein in the formula I, R1 and R2 are respectively and independently selected from hydrogen, alkoxy, aryl, benzyl or fluorine. The synthesis method comprises the following steps: S1, under the action of a non-noble metal catalyst, carrying out continuous methylation reaction on a compound A and a methyl Grignard reagent B to obtain a compound C, wherein the compound A is a compound shown in the specification, the compound C is a compound shown in the specification, R1 and R2 are respectively and independently selected from hydrogen, alkoxy, aryl, benzyl or fluorine, and the non-noble metal catalyst is one or more of ferric salt, cobalt salt and nickel salt; and S2, carrying out continuous oxidation reaction on the compound C under the action of oxygen, an oxidation catalyst and an additive, and thus obtaining the 2-chloropyrimidine-4-formic acid compound. By adopting the process provided by the invention to synthesize the 2-chloropyrimidine-4-formic acid compound, the aspects of cost, yield,environmental friendliness and the like can be considered.

6-substituted pyrimidyl quinazolinone compound and application thereof

The invention discloses a 6-substituted pyrimidyl quinazolinone compound having a novel structure represented as the general formula (I) and a salt thereof, wherein the substituent groups in the formula are defined as the specification. The compound has excellent insecticidal activity and can be used for preventing and treating insect pests in agriculture, forestry or non-treatment target, especially, the application for preventing and treating aphids.