130655-38-8Relevant academic research and scientific papers
A PRACTICAL ROUTE TO SPIRO-TYPE HETEROCYCLES RELATED TO ERYTHRINAN
Tsuda, Yoshisuke,Sakai, Yuki,Kaneko, Mari,Ishiguro, Yukie,Isobe, Kimiaki,et al.
, p. 431 - 436 (2007/10/02)
A new method synthesizing spiro-type heterocycles by intramolecular cyclization of 3,3-disubstituted dioxopyrrolines was presented.The method is particularly useful in synthesizing erythrinans and has the following advantages: 1) it is of short steps with high yield ( one-pot reaction is possible ), 2) an activating group at ring A is not necessary, and 3) the procedure can be carried out without protection of phenolic hydroxyl groups.Wide applicability of this method was also shown by synthesizing C-nor and C-homoerythrinans, and other variants which carry heterocycles at ring A instead of benzenoids.
