130657-41-9Relevant academic research and scientific papers
SYNTHESIS OF BENZOPHENANTHRIDINES FROM 2-AMINO-6,7-DIMETHOXY-3-(3,4-DIMETHOXYPHENYL)-1,4-NAPHTHOQUINONE
Gogilashvili, T. I.,Kurkovskaya, L. N.,Akhvlediani, R. N.,Suvorov, N. N.
, p. 992 - 996 (2007/10/02)
Previously unknown benzophenanthridines with methoxyl substituents in rings A and D were synthesized from 2-amino-6,7-dimethoxy-3-(3,4-dimethoxyphenyl)-1,4-naphthoquinone by N-acylation, reductive acylation, and Bischler-Napieralskii cyclization.The products are of interest in relation to their structural affinity to the highly active antileukemia benzophenanthridine alkaloids.The optimum conditions for the production of 7,12-diacetoxy-5-methyl-2,3,9,10-tetramethoxybenzophenanthridine with high yields were determined.Its hydrolysis by water in boiling dimethyl formamide led to the product from deacetylation at position 7.
