1543-31-3

Upstream product

• 39769-09-0 4-fluoro-N-[(1E/Z)-(4-fluorophenyl)methylene]aniline 
• 127-17-3 2-oxo-propionic acid 
• 2146-07-8 p-fluoroaniline hydrochloride 
• 371-40-4 4-fluoroaniline 
• 351-09-7 N-(4-fluorophenyl)-2-(hydroxyimino) acetamide 
• 443-69-6 5-fluoro-1H-indole-2,3-dione 
• 403-42-9 1-(4-fluorophenyl)ethanone 

Downstream Products

• 1394063-80-9 4-(5,6-dichloro-1H-benzimidazol-2-yl)-6-fluoro-2-(4-fluorophenyl)quinoline 
• 1394063-79-6 6-fluoro-2-(4-fluorophenyl)-4-(1H-imidazo[4,5-b]pyridin-2-yl)quinoline 
• 1394063-81-0 6-fluoro-4-(5-fluoro-1H-benzimidazol-2-yl)-2-(4-fluorophenyl)quinoline 
• 1394063-78-5 4-(5-chloro-1H-benzimidazol-2-yl)-6-fluoro-2-(4-fluorophenyl)quinoline 
• 1394063-77-4 4-(1H-benzo[d]imidazol-2-yl)-6-fluoro-2-(4-fluorophenyl)quinoline 
• 1453176-95-8 C₁₆H₈ClF₂NO 
• 1596354-75-4 3-(2-(4-fluorophenyl)-6-fluoroquinolin-4-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole-6-thiol 
• 1596354-74-3 4-amino-5-(2-(4-fluorophenyl)-6-fluoroquinolin-4-yl)-4H-1,2,4-triazole-3-thiol 
• 1306588-48-6 5-(2-(4-fluorophenyl)-6-fluoro-quinolin-4-yl)-1,3,4-oxadiazole-2-thiol 
• 1596354-73-2 N-(2,5-dimethyl-1H-pyrrol-1-yl)-6-fluoro-2-(4-fluorophenyl)quinoline-4-carboxamide 
• 1596354-72-1 1-(2-(4-fluorophenyl)-6-fluoroquinolin-4-carbonyl)-3-methyl-5-phenyl-1H-pyrazole 
• 1596354-71-0 1-(2-(4-fluorophenyl)-6-fluoroquinolin-4-carbonyl)-3,5-dimethyl-1H-pyrazole 
• 1596354-70-9 N-(4-methoxyphenyl)-5-(6-fluoro-2-(4-fluorophenyl)quinolin-4-yl)-4H-1,2,4-triazol-3-amine 
• 1596354-69-6 N-(p-tolyl)-5-(6-fluoro-2-(4-fluorophenyl)quinolin-4-yl)-4H-1,2,4-triazol-3-amine 

Relevant academic research and scientific papers

Synthesis, molecular modeling and anti-inflammatory screening of novel fluorinated quinoline incorporated benzimidazole derivatives using the Pfitzinger reaction

Several new fluorinated quinoline derivatives were synthesized and tested for their anti-inflammatory and ulcerogenic effect. A docking study on the COX-2 binding pocket was carried out for the target compounds to rationalize the possible selectivity of them against COX-2 enzyme. The most active compounds (3, 2, 7 and 11) were found to be superior to celecoxib as they were devoid of any ulcerogenic activity. Compound 3a demonstrated the highest anti-inflammatory activity as well as the best binding profiles into the COX-2 binding site. Moreover, compounds 3-12 were screened for antibacterial activity and none of them showed noteworthy activity.

Design, synthesis and antitumour activity of bisquinoline derivatives connected by 4-oxy-3-fluoroaniline moiety

A series of novel bisquinoline derivatives connected by a 4-oxy-3-fluoroaniline moiety were synthesized and evaluated for their in vitro antitumour activities against a panel of five cancer cell lines (H460, HT-29, MKN-45, U87MG, and SMMC-7721). Most of compounds tested showed a potent activity and high selectivity towards the H460 and MKN-45 cell lines. Among the compounds tested, six (15d, 15e, 15m, 15n, 16a, and 16i) were further examined for their c-Met kinase activity; the compounds showed high efficacy with IC 50 values in the single-digit nM range. An analysis of structure-activity relationships indicated that an unsubstituted or a halogen-substituted phenyl ring on the 2-arylquinoline-4-carboxamide moiety was favourable for antitumour activity.

Synthesis, characterization and antimicrobial studies of some new quinoline incorporated benzimidazole derivatives

Two new series of quinoline incorporated benzimidazole derivatives (4a-i and 8a-f) were synthesized from substituted aniline and isatin through multi-step reaction. 6-substituted-4-carboxyquinolines (3a,b and 7) were synthesized by multi component one pot