130676-99-2Relevant academic research and scientific papers
A minimalistic approach to identify substrate binding features in B1 Metallo-β-lactamases
Poeylaut-Palena, Andres A.,Tomatis, Pablo E.,Karsisiotis, Andreas I.,Damblon, Christian,Mata, Ernesto G.,Vila, Alejandro J.
, p. 5171 - 5174 (2008/03/14)
The 2-oxoazetidinylacetate sodium salt was synthesized as a model of a minimal β-lactam drug. This compound and the monobactam aztreonam were assayed as substrates of the Metallo-β-lactamase BcII. None of them was hydrolyzed by the enzyme. While the azeti
Studies on the Biosynthesis of Clavulanic Acid. Part 4. Synthetic Routes to the Monocyclic β-Lactam Precursor, Proclavaminic Acid
Baggaley, Keith H.,Elson, Stephen W.,Nicholson, Neville H.,Sime, John T.
, p. 1513 - 1520 (2007/10/02)
Aldol condensation of 3-substituted propionaldehydes with the lithium enolate of ethyl or benzyl(2-oxoazetidin-1-yl)acetate yielded derivatives of proclavaminic acid.The proportion of the threo diastereoisomer in the aldol product could be increased by th
