1306763-29-0

Basic information

• Product Name: (R)-1-amino-2,3-dihydro-1H-indene-4-carbonitrile hydrochloride
• Synonyms: (R)-(1-amino-2,3-dihydro-1H-indene-1-yl)-4-carbonitrile hydrochloride
• CAS NO: 1306763-29-0
• Molecular Formula: C₁₀H₁₀N₂*ClH
• Molecular Weight: 194.66074
• EINECS: -0
• Mol File: 1306763-29-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (R)-1-amino-2,3-dihydro-1H-indene-4-carbonitrile hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-amino-2,3-dihydro-1H-indene-4-carbonitrile hydrochloride(1306763-29-0)
• EPA Substance Registry System: (R)-1-amino-2,3-dihydro-1H-indene-4-carbonitrile hydrochloride(1306763-29-0)

Safety Data

• Hazardous Substances Data: 1306763-29-0(Hazardous Substances Data)

Usage

Description

(R)-1-amino-2,3-dihydro-1H-indene-4-carbonitrile hydrochloride, commonly known as Rolipram, is a chemical compound characterized by its potent and selective inhibition of the enzyme phosphodiesterase 4 (PDE4). This enzyme is integral to the inflammatory response and the regulation of airway smooth muscle contractility. Rolipram's ability to inhibit PDE4 makes it a significant compound in the treatment of various respiratory and mood disorders.

Uses

Used in Pharmaceutical Industry:
(R)-1-amino-2,3-dihydro-1H-indene-4-carbonitrile hydrochloride is used as an anti-inflammatory agent for the treatment of chronic obstructive pulmonary disease (COPD) and asthma. Its mechanism of action involves the inhibition of PDE4, which leads to a reduction in inflammation and bronchoconstriction in the airways, thereby improving respiratory symptoms.
Used in Respiratory Medicine:
In the treatment of respiratory conditions, (R)-1-amino-2,3-dihydro-1H-indene-4-carbonitrile hydrochloride is used as a bronchodilator to alleviate airway constriction and improve lung function in patients with asthma and COPD.
Used in Psychiatric Research:
(R)-1-amino-2,3-dihydro-1H-indene-4-carbonitrile hydrochloride is used as a potential anti-depressant in research settings. Its effects on PDE4 are being studied for their potential to influence mood regulation, although its application in this area is not yet widely accepted for clinical use.
Used in Drug Development:
In the field of drug development, (R)-1-amino-2,3-dihydro-1H-indene-4-carbonitrile hydrochloride serves as a lead compound for the development of new therapeutic agents targeting PDE4, with the aim of discovering more effective treatments for inflammatory and mood disorders.

Upstream product

• 1306763-28-9 (R)-N-((R)-4-cyano-2,3-dihydro-1H-inden-1-yl)-2-methylpropane-2-sulfinamide 
• 1306763-27-8 (R)-N-(4-cyano-2,3-dihydro-1H-indene-1-ylidene)-2-methylpropane-2-sulfinamide 
• 15115-60-3 4-bromo-2,3-dihydroinden-1-one 
• 60899-34-5 4-cyano-2,3-dihydro-1H-inden-1-one 

Downstream Products

• 1306763-30-3 (R)-tert-butyl 4-cyano-2,3-dihydro-1H-inden-1-ylcarbamate 
• 1306763-71-2 (R)-tert-butyl 4-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ylcarbamate 
• 1307231-27-1 (R)-tert-butyl (2-((tert-butyldimethylsilyl)oxy)ethyl)(4-(N-((4-phenyl-5-(trifluoromethyl)thiophene-2-carbonyl)oxy)carbamimidoyl)-2,3-dihydro-1H-inden-1-yl)carbamate 
• 1307231-07-7 (R)-tert-butyl 2-(tert-butyldimethylsilyloxy)ethyl(4-(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)carbamate 
• 1306763-42-7 (R)-tert-butyl 2-(tert-butyldimethylsilyloxy)ethyl(4-(N-hydroxycarbamimidoyl)-2,3-dihydro-1H-inden-1-yl)carbamate 
• 1306763-41-6 (R)-tert-butyl 2-(tert-butyldimethylsilyloxy)ethyl(4-cyano-2,3-dihydro-1H-inden-1-yl)carbamate 
• 1307231-06-6 (R)-tert-butyl 4-(5-(3,4-diethoxybenzyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ylcarbamate 
• 1213203-23-6 (R)-(1-amino-2,3-dihydro-1H-indene-1-yl)-4-carbonitrile 

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