Welcome to LookChem.com Sign In|Join Free

CAS

  • or

1306763-29-0

Post Buying Request

1306763-29-0 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

1306763-29-0 Usage

Description

(R)-1-amino-2,3-dihydro-1H-indene-4-carbonitrile hydrochloride, commonly known as Rolipram, is a chemical compound characterized by its potent and selective inhibition of the enzyme phosphodiesterase 4 (PDE4). This enzyme is integral to the inflammatory response and the regulation of airway smooth muscle contractility. Rolipram's ability to inhibit PDE4 makes it a significant compound in the treatment of various respiratory and mood disorders.

Uses

Used in Pharmaceutical Industry:
(R)-1-amino-2,3-dihydro-1H-indene-4-carbonitrile hydrochloride is used as an anti-inflammatory agent for the treatment of chronic obstructive pulmonary disease (COPD) and asthma. Its mechanism of action involves the inhibition of PDE4, which leads to a reduction in inflammation and bronchoconstriction in the airways, thereby improving respiratory symptoms.
Used in Respiratory Medicine:
In the treatment of respiratory conditions, (R)-1-amino-2,3-dihydro-1H-indene-4-carbonitrile hydrochloride is used as a bronchodilator to alleviate airway constriction and improve lung function in patients with asthma and COPD.
Used in Psychiatric Research:
(R)-1-amino-2,3-dihydro-1H-indene-4-carbonitrile hydrochloride is used as a potential anti-depressant in research settings. Its effects on PDE4 are being studied for their potential to influence mood regulation, although its application in this area is not yet widely accepted for clinical use.
Used in Drug Development:
In the field of drug development, (R)-1-amino-2,3-dihydro-1H-indene-4-carbonitrile hydrochloride serves as a lead compound for the development of new therapeutic agents targeting PDE4, with the aim of discovering more effective treatments for inflammatory and mood disorders.

Check Digit Verification of cas no

The CAS Registry Mumber 1306763-29-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,0,6,7,6 and 3 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1306763-29:
(9*1)+(8*3)+(7*0)+(6*6)+(5*7)+(4*6)+(3*3)+(2*2)+(1*9)=150
150 % 10 = 0
So 1306763-29-0 is a valid CAS Registry Number.

1306763-29-0Relevant articles and documents

COMPOUNDS AND METHODS FOR TREATING LUPUS

-

, (2018/04/17)

Methods for treatment of systemic lupus erythematosus (SLE" or "Lupus") by administration of a modulator of sphingosine-1-phosphate receptor subtype 1 (S1P1), as well as compositions and methods related to the same, wherein such S1P1 modulators have the f

SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS

-

, (2011/06/16)

Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1306763-29-0