1306763-57-4

Usage

Uses

Used in Pharmaceutical Research:
(S)-1-amino-2,3-dihydro-1H-indene-4-carbonitrile hydrochloride is utilized as a chiral building block for the development of new pharmaceutical agents, leveraging its unique structural features to create novel drug candidates with potential therapeutic applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (S)-1-amino-2,3-dihydro-1H-indene-4-carbonitrile hydrochloride is employed as a key intermediate in the synthesis of biologically active molecules, contributing to the discovery of new drugs with improved efficacy and selectivity.
Used in Chemical Research:
(S)-1-amino-2,3-dihydro-1H-indene-4-carbonitrile hydrochloride serves as a valuable compound in chemical research, enabling the exploration of its reactivity and potential applications in organic synthesis, including the creation of new chemical entities with diverse properties and functions.

Upstream product

• 60899-34-5 4-cyano-2,3-dihydro-1H-inden-1-one 
• 1306763-31-4 tert-butyl N-[(1S)-4-cyano-2,3-dihydro-1H-inden-1-yl]carbamate 

Downstream Products

• 1306763-62-1 (S)-tert-butyl 2-(tert-butyldimethylsilyloxy)ethyl-(4-(N-hydroxycarbamimidoyl)-2,3-dihydro-1H-inden-1-yl)carbamate 
• 1306760-86-0 5-(3-{(1S)-1-[(2-hydroxyethyl)amino]-2,3-dihydro-1H-inden-4-yl}-1,2,4-oxadiazol-5-yl)-2-[(propan-2-yl)oxy]benzonitrile 
• 1306763-31-4 tert-butyl N-[(1S)-4-cyano-2,3-dihydro-1H-inden-1-yl]carbamate 

Relevant academic research and scientific papers

IMPROVED PROCESS FOR PREPARING OZANIMOD

The presented invention relates to a process for preparation of compound of formula (1) or a salt thereof (i.e.) ozanimod : (1). The invention also relates to intermediates used in the process.

IMPROVED PROCESS FOR THE PREPARATION OF OZANIMOD Α-AMINO COMPOUND

The present invention relates to an improved process for the preparation of optically chiral amino compound. The present invention particularly relates to the improved process for the preparation of (S)-1-amino-2,3-dihydro-1H-indene-4-carbonitrile, an important intermediate for the synthesis of ozanimod. The present invention more particularly relates to preparation of (S)-1-amino-2,3-dihydro-1H-indene-4- carbonitrile using 4-cyano-1-indanone and α-methylbenzylamine derivatives as starting materials. The present invention specifically relates to preparation of (S)-1- amino-2,3-dihydro-1H-indene-4-carbonitrile comprising diastereoselective chiral amine synthesis by protection with chiral auxiliary ?-methyl benzylamine derivatives followed by reduction and debenzylation.

COMPOUNDS AND METHODS FOR TREATING LUPUS

Methods for treatment of systemic lupus erythematosus (SLE" or "Lupus") by administration of a modulator of sphingosine-1-phosphate receptor subtype 1 (S1P1), as well as compositions and methods related to the same, wherein such S1P1 modulators have the f

SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS

Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.