130677-08-6

Upstream product

• 130677-07-5 sodium (2-oxo-azetidin-1-yl)acetate 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 114342-03-9 benzyl (2-oxo-azetidin-1-yl)acetate 
• 130676-99-2 benzyl (3-bromopropionamido)acetate 

Downstream Products

• 130677-10-0 (2S,3R)-4-bromobenzyl 5-(4,5-bismethoxycarbonyl-1,2,3-triazol-1-yl)-3-hydroxy-2-(2-oxoazetidin-1-yl)valerate 
• 130793-34-9 (2S,3R)-4-bromobenzyl 5-azido-3-hydroxy-2-(2-oxoazetidin-1-yl)valerate 

Relevant academic research and scientific papers

Studies on the Biosynthesis of Clavulanic Acid. Part 4. Synthetic Routes to the Monocyclic β-Lactam Precursor, Proclavaminic Acid

Aldol condensation of 3-substituted propionaldehydes with the lithium enolate of ethyl or benzyl(2-oxoazetidin-1-yl)acetate yielded derivatives of proclavaminic acid.The proportion of the threo diastereoisomer in the aldol product could be increased by th