130697-53-9

Upstream product

• 130632-03-0 1-[(1R,2S,5R)-(-)-(menthyloxycarbonyl)methyl]-2,2,5,5-tetramethyl-2,5-disila-1-azacyclopentane 
• 1624-46-0 (E)-1,N-bis(4-methoxyphenyl)methanimine 

Relevant academic research and scientific papers

ASYMMETRIC SYNTHESIS OF β-LACTAMS BY CHIRAL ESTER ENOLATE-IMINE CONDENSATION

Asymmetric cyclocondensation of N,N-bis(silyl)glycinates bearing chiral ester moieties with aldimines is found to proceed with extremely high enantioselectivity to give the corresponding chiral β-lactams in good to high yields.It is found that the E/Z-geometry of the chiral ester-enolate is responsible for cis/trans stereochemistry of the β-lactam formed.Effects of various chiral auxiliaries in the ester-enolates on the enantioselectivity of the reactions are examined.