130697-85-7

Upstream product

• 917-54-4 methyllithium 
• 118993-51-4 (3aα,4α,5β,6β,7β,7aα)-4,5-bis(benzyloxy)-6,7-epoxyhexahydro-2,2-dimethylbenzo-1,3-dioxole 
• 71-43-2 benzene 

Downstream Products

• 52770-21-5 (1α,2α,3α,4β,5α,6β)-6-methyl-1,2,3,4,5-cyclohexanepentol 
• 125291-11-4 (3aα,4α,5β,6α,7β,7aα)-hexahydro-2,2,6-trimethylbenzo-1,3(2H)-dioxol-4,5,7-triol tris(dibenzylphosphate) 
• 125305-58-0 (1α,2β,3α,4α,5α,6β)-6-methyl-1,2,3,4,5-cyclohexanepentol 1,2,5-trisphosphate 

Relevant academic research and scientific papers

MICROBIAL OXIDATION IN SYNTHESIS: PREPARATION OF 6-DEOXY CYCLITOL ANALOGUES OF MYO-INOSITOL 1,4,5-TRIPHOSPHATE FROM BENZENE

The novel 6-deoxy, 6-deoxy-6-fluoro and 6-deoxy-6-methyl myo-inositol 1,4,5-triphosphate derivatives (4), (5) and (6) were derived from benzene via microbial oxidation to cis -1,2-dihydroxycyclohexa-3,5-diene (2) and conversion through to the key epoxyace

MICROBIAL OXIDATION IN SYNTHESIS: PREPARATION OF MYO-INOSITOL PHOSPHATES AND RELATED CYCLITOL DERIVATIVES FROM BENZENE.

Pseudomonas putida oxidation of benzene affords cis-3,5-cyclohexadiene-1,2-diol (2) which is used as a novel precursor for the synthesis of D- and L-myo-inositol 1,4,5-triphosphates, (-)-(1) and (+)-(1).The versatility of this approach to functionalised cyclitols is illustrated in the synthesis of myo-inositol 1-phosphate (19), 6-deoxy, 6-deoxy-6-fluoro, and 6-deoxy-6-methyl myo-inositols (31), (37) and (43), and their 1,4,5-trisphosphate derivatives (33), (39) and (45).