130707-75-4Relevant academic research and scientific papers
Improved synthesis of the bifunctional chelating agent 1,4,7,10- tetraaza-N-(1-carboxy-3-(4-nitrophenyl)propyl)-N',N'',N'''-tris(acetic acid)cyclododecane (PA-DOTA)
Chappell, Lara L.,Rogers, Buck E.,Khazaeli,Mayo, Matthew S.,Buchsbaum, Donald J.,Brechbiel, Martin W.
, p. 2313 - 2320 (2007/10/03)
A concise synthesis of the bifunctional chelating agent 1,4,7,10- tetraaza-N-(1-carboxy-3-(4-nitrophenyl)propyl)-N','',N'''-tris(acetic acid)cyclododecane (PA-DOTA) is reported. Difficulties involving the production of partially alkylated products and the
Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic and therapeutic agents
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, (2008/06/13)
A group conjugates having a functionalized polyaminocarboxylate chelant that form complexes with rare earth-type metal ions, covalently attached to an antibody or antibody fragment, can be used for therapeutic and/or diagnostic purposes.
