130710-65-5Relevant academic research and scientific papers
Chemical Synthesis of 3-Ethylcompactin, an Inhibitor of 3-Hydroxy-3-methylglutarylcoenzyme A Reductase
Clive, Derrick L. J.,Murthy, K. S. Keshava,George, Rajan,Poznansky, Mark J.
, p. 2099 - 2108 (2007/10/02)
A method is described for stereocontrolled synthesis of (+)-3-ethylcompactin (1c), a compound that inhibits rat liver HMG CoA reductase with a similar potency to mevinolin.The synthetic approach is a general one and involves linking a pent-4-enal (3) with
