130715-41-2Relevant academic research and scientific papers
Convenient synthesis and anti-proliferative activity of some benzochromenes and chromenotriazolopyrimidines under classical methods and phase transfer catalysis
Ali, Amira T.,Hekal, Mohamed H.
, p. 3498 - 3509 (2019)
A new series of benzochromene, benzochromenopyrimidine, and benzotriazolopyrimdine derivatives 3-10 were prepared via reaction of ethyl formimidate 2 with primary amines such as sulfanilamide, cyclohexylamine, 3-aminopyridine, 4-aminoantipyrine in addition to its reactions with different acid hydrazides. Compound 5 was further allowed to react with different C-electrophiles by classical and phase transfer catalysis conditions to get novel chromenotriazolopyrimidine derivatives. Screening of the antitumor activity in some of the newly synthesized compounds was tested in vitro against a panel of two human tumor cell lines namely HepG2 and HCT-116 cell lines. Compounds 4, 7, 8, 10, and 20 showed remarkable broad-spectrum antitumor activity.
Photochemical synthesis of benzo[: F] chromene
Akbari
, p. 1778 - 1783 (2017/12/26)
The one-pot photocatalytic synthesis of benzo[f]chromene was performed at room temperature by the addition of benzyl alcohol, malononitrile and β-naphthol in contact with an illuminated nano-SnO2/TiO2 composite. This study illustrated the potential of photochemical synthesis of benzo[f]chromene. A simple procedure was proposed for the synthesis of a nano-SnO2/TiO2 composite using the sol-gel method by hydrolysis of tin(iv) chloride and titanium(iv) chloride at room temperature in the presence of polyethylene glycol 200, diethanolamine, and distilled water. Scanning electron microscopy (SEM), X-ray diffraction (XRD), and FT-IR were employed to characterize the proposed photocatalyst.
Action of primary amines and hydroxylamine on ethoxymethyleneaminonaphtopyranes: Synthesis of new naphtopyrano [2,3-d] pyrimidines derivatives
Messaad, Mehadi,Chabchoub, Fakher,Salem, Mansour
, p. 139 - 144 (2007/10/03)
A variety of naphtopyrans 1 has been prepared by reaction of 2-naphtol with aryl (or alkyl) idenemalononitriles. The reaction of the naphtopyrans with triethylorthoformiate and then with primary amines and hydroxylamine, leads to new naphtopyrano [2, 3-d] pyrimidines 3 and 4, whose structures were confirmed by IR and NMR spectroscopy.
Heterocycles synthesis through reactions of nucleophiles with acrylonitriles: Part XI - A convenient one-pot synthesis of 4H-chromenes
Abdel-Latif
, p. 664 - 666 (2007/10/02)
Several new 4H-chromenes (IVa-j and Va-j) have been synthesised by a one-step and facile method in excellent yields. The reaction mechanism is also reported.
