1307233-43-7Relevant academic research and scientific papers
Au(I)/(R)-BINOL-Ti(IV) concerted catalyzed asymmetric cascade cycloaddition reaction of arylalkynols
Wang, Hongkai,Zeng, Tianlong,Chang, Weixing,Liu, Lingyan,Li, Jing
, p. 3573 - 3577 (2021)
An efficient catalytic asymmetric cascade cycloaddition reaction of arylalkynols with dioxopyrrolidines was developed. This reaction was achieved using Au(I) and (R)-BINOL-Ti(IV) bimetallic catalysts and exclusively delivered a series of chiral oxo-bridged bicyclic benzooxacine compounds in up to 86% yield with 96% ee as well as >33:1 dr. Meanwhile, three new σ bonds and three new stereogenic centers were formed in a one-pot process.
An efficient route to chiral N-heterocycles bearing a C-F stereogenic center via asymmetric hydrogenation of fluorinated isoquinolines
Guo, Ran-Ning,Cai, Xian-Feng,Shi, Lei,Ye, Zhi-Shi,Chen, Mu-Wang,Zhou, Yong-Gui
supporting information, p. 8537 - 8539 (2013/09/23)
An efficient iridium-catalyzed asymmetric hydrogenation of the fluorinated isoquinoline derivatives has been successfully developed for the synthesis of chiral fluorinated tetrahydroisoquinoline derivatives with up to 93% ee. This methodology features the use of a hydrochloride salt as well as a catalytic amount of halogenated hydantoin which were vital for the reactivity, enantioselectivity, and inhibition of the hydrodefluorination pathway. The Royal Society of Chemistry 2013.
