Organic Letters p. 3573 - 3577 (2021)
Update date:2022-08-04
Topics:
Wang, Hongkai
Zeng, Tianlong
Chang, Weixing
Liu, Lingyan
Li, Jing
An efficient catalytic asymmetric cascade cycloaddition reaction of arylalkynols with dioxopyrrolidines was developed. This reaction was achieved using Au(I) and (R)-BINOL-Ti(IV) bimetallic catalysts and exclusively delivered a series of chiral oxo-bridged bicyclic benzooxacine compounds in up to 86% yield with 96% ee as well as >33:1 dr. Meanwhile, three new σ bonds and three new stereogenic centers were formed in a one-pot process.
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