1307273-34-2

Upstream product

• 1091820-63-1 ethyl 4-(4-chlorophenyl)-1,2-dihydro-6-methyl-2-oxopyrimidine-5-carboxylate 
• 66003-76-7 Diphenyliodonium triflate 
• 1091820-63-1 C₁₄H₁₃ClN₂O₃ 
• 108-95-2 phenol 

Relevant academic research and scientific papers

Direct metal-free O-arylation of Biginelli 4-aryl-6-methyl-pyrimidine-2(1H)-one derivatives using diaryliodonium salts

4-Aryl-6-methyl-pyrimidine-2(1H)-one scaffolds of Biginelli type were subjected to C-O cross-coupling reactions using symmetrical diaryliodonium salts under transition metal-free conditions to afford 2-aryloxy pyrimidine derivatives in good to excellent y

Synthesis of C2-functionalized pyrimidines from 3,4-dihydropyrimidin-2(1H)- ones by the Mitsunobu coupling reaction

The Biginelli 3,4-dihydropyrimidin-2(1H)-one was converted to various C2-multifunctionalized pyrimidines via the dehydrogenation and Mitsunobu reaction using amines, alcohols, phenols and carboxylic acids as nucleophiles. A possible mechanism was also proposed to rationalize the formation of products.