130734-39-3

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 105-45-3 acetoacetic acid methyl ester 
• 552-89-6 2-nitro-benzaldehyde 
• 67-56-1 methanol 
• 15887-39-5 5-(2-nitrobenzylidene)-2,2-dimethyl-1,3-dioxan-4,6-dione 

Downstream Products

• 928205-89-4 2-Methyl-4-(2-nitrophenyl)-6-oxo-1,6-dihydropyridin-3-carbonsaeuremethylester 
• 882296-26-6 methyl 6-chloro-5-formyl-2-methyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-3-carboxylate 
• 1314745-66-8 methyl 2-methyl-4-(2-nitrophenyl)-6-thioxo-1,4,5,6-tetrahydropyridine-3-carboxylate 
• 928206-00-2 (R,S)-6-{[4-(Diethylamino)-1-methylbutyl]amino}-2-methyl-4-(2-nitrophenyl)-nicotinsaeuremethylester 
• 928205-90-7 6-Chlor-2-methyl-4-(2-nitrophenyl)-pyridin-3-carbonsaeuremethylester 

Relevant academic research and scientific papers

High-throughput preparation of alkyl 4-aryl substituted-2-methyl-6-thioxo- 1,4,5,6-tetrahydropyridine-3-carboxylates under microwave irradiation

An efficient high-throughput synthesis of 4-aryl substituted 1,4,5,6-tetrahydro-2-methyl-6-thioxopyridine-3-carboxylates 5a-p was developed by using Lawesson's reagent, a very effective thionating reagent for carbonyl compounds, under conventional conditi

Solid-phase synthesis of 4-aryl substituted 5-carboxy-6-methyl-3,4-dihydropyridones

Substituted 3,4-dihydro-2-pyridones have been efficiently prepared by solid-phase synthesis using Wang resin from the immobilised β-ketoester and further Hantzsch-type heterocyclisation.

Novel hexahydrofuro[3,4-b]-2(1H)-pyridones from 4-aryl substituted 5-alkoxycarbonyl-6-methyl-3,4-dihydropyridones

The title compounds 6 have been prepared in a one-step procedure from the corresponding 4-aryl substituted 5-alkoxycarbonyl-6-methyl-3,4-dihydropyridones 4 in good yields. Quantum chemical calculations reveal a non-planar molecule with a distorted dihydropyridone ring and two favoured conformations. The 13C nmr data and theoretical calculations support a strong push-pull effect on the olefinic moiety.

Oxygen-bridged Tetrahydropyridines, Hexahydropyridines, and Dihydropyridones via a Hantzsch-like Synthesis with 4-(2-Hydroxyphenyl)but-3-en-2-one

Substituted oxygen-bridged tetrahydro-2-pyridones and tetrahydropyridines (4) and (7) were synthesized by condensation of 4-(2-hydroxyphenyl)but-3-en-2-one (1) with Meldrum's acid (2) and 3-aminocrotononitrile, respectively, in the presence of ammonium ac