130749-73-4

Upstream product

• 130749-66-5 -5-(2-benzoylvinyl)-2,4-dimethoxypyrimidine 
• 130749-58-5 5-(3-hydroxy-3-phenyl-prop-1-enyl)-2,4-dimethoxypyrimidine 
• 130749-52-9 E-5-(2-formylvinyl)-2,4-dimethoxypyrimidine 
• 122352-89-0 5-(2-hydroxymethylethynyl)-2,4-dimethoxypyrimidine 
• 130749-51-8 E-5-(3-hydroxy-prop-1-enyl)-2,4-dimethoxypyrimidine 
• 768-03-6 Phenyl vinyl ketone 
• 100-52-7 benzaldehyde 
• 4187-87-5 1-Phenyl-2-propyn-1-ol 
• 4393-06-0 1-Phenyl-2-propen-1-ol 

Relevant academic research and scientific papers

Synthesis and biological activities of [E]-5-(2-acylvinyl)uracils

The synthesis of a number of 5-substituted uracils, eg [E]-5-(2-acylvinyl)uracils 8a-8g is described. These compounds were found to have cytotoxic activities against CCRF-CEM human lymphoblastoid cells, HT-29 colon carcinoma cells and L1210/0 mouse leukemia cells. These compounds were also found to inhibit thymidylate synthase.

SYNTHESIS OF NOVEL 5-(2-ACYLVINYL)URACILS

5-(3-Hydroxyprop-1-ynyl)-2,4-dimethoxypyrimidine (1) on treatment with lithium aluminium hydride in tetrahydrofuran yielded 5-(3-hydroxyprop-1-enyl)-2,4-dimethoxypyrimidine (2) which on oxidation with manganese dioxide in dichloromethane led to 5-(2-formy

A Highly Convenient Procedure for the Synthesis of 5-(2-Acylvinyl)uracils, a Group of Novel 5-Substituted Uracils

An unambiguous and efficient method has been developed for the synthesis of a number of 5-(2-acylvinyl)uracils, which are of interest as anticancer, antiviral, and anti-AIDS agents.