130749-75-6

Upstream product

• 130767-31-6 (E)-3-(2,4-Dimethoxy-pyrimidin-5-yl)-1-(4-methoxy-phenyl)-propenone 
• 51410-44-7 1-(4-methoxylphenyl)-2-propen-1-ol 
• 7448-86-4 1-(4-methoxyphenyl)prop-2-en-1-one 
• 130749-60-9 5-(3-hydroxy-3-p-methoxyphenyl-prop-1-enyl)-2,4-dimethoxypyrimidine 
• 130749-52-9 E-5-(2-formylvinyl)-2,4-dimethoxypyrimidine 
• 122352-89-0 5-(2-hydroxymethylethynyl)-2,4-dimethoxypyrimidine 
• 130749-51-8 E-5-(3-hydroxy-prop-1-enyl)-2,4-dimethoxypyrimidine 
• 123-11-5 4-methoxy-benzaldehyde 
• 19115-30-1 1-(4-methoxyphenyl)-2-propyn-1-ol 

Relevant academic research and scientific papers

Synthesis and biological activities of [E]-5-(2-acylvinyl)uracils

The synthesis of a number of 5-substituted uracils, eg [E]-5-(2-acylvinyl)uracils 8a-8g is described. These compounds were found to have cytotoxic activities against CCRF-CEM human lymphoblastoid cells, HT-29 colon carcinoma cells and L1210/0 mouse leukemia cells. These compounds were also found to inhibit thymidylate synthase.

SYNTHESIS OF NOVEL 5-(2-ACYLVINYL)URACILS

5-(3-Hydroxyprop-1-ynyl)-2,4-dimethoxypyrimidine (1) on treatment with lithium aluminium hydride in tetrahydrofuran yielded 5-(3-hydroxyprop-1-enyl)-2,4-dimethoxypyrimidine (2) which on oxidation with manganese dioxide in dichloromethane led to 5-(2-formy

A Highly Convenient Procedure for the Synthesis of 5-(2-Acylvinyl)uracils, a Group of Novel 5-Substituted Uracils

An unambiguous and efficient method has been developed for the synthesis of a number of 5-(2-acylvinyl)uracils, which are of interest as anticancer, antiviral, and anti-AIDS agents.