130753-13-8

Usage

Uses

Used in Pharmaceutical Industry:
N-Cbz-Nortropinone is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to facilitate the creation of complex molecules with potential medicinal properties. Its unique structure allows for the development of drugs targeting specific biological pathways, contributing to the advancement of novel therapeutic agents.
Used in Organic Chemistry:
In the realm of organic chemistry, N-Cbz-Nortropinone is utilized as a valuable building block for the production of other chemical compounds. Its reactivity and chemical properties make it an essential component in the synthesis of a wide range of organic molecules, thereby expanding the scope of chemical research and applications.
Used in Drug Development:
N-Cbz-Nortropinone plays a pivotal role in drug development as a precursor for the synthesis of molecules with potential therapeutic applications. Its involvement in the creation of new drugs highlights its significance in the pharmaceutical sector, where it aids in the discovery and production of innovative medications to address various health conditions.

InChI:InChI=1/C15H17NO3/c17-14-8-12-6-7-13(9-14)16(12)15(18)19-10-11-4-2-1-3-5-11/h1-5,12-13H,6-10H2

Upstream product

• 96951-89-2 benzyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 532-24-1 tropinone 
• 501-53-1 benzyl chloroformate 
• 185099-67-6 Boc-tropinone 
• 478837-18-2 3-exo-hydroxy-8-azabicyclo[3.2.1]octane-8carboxylic acid tert-butyl ester 
• 542-05-2 acetonedicarboxylic acid 
• 28957-72-4 N-benzyltropinone 
• 5632-84-8 nortropinone 
• 25602-68-0 3-oxo-8-azabicyclo[3.2.1]octane hydrochloride 

Downstream Products

• 257628-72-1 3-(1H-indol-3-yl)-8-aza-bicyclo[3.2.1]oct-2-ene-8-carboxylic acid benzyl ester 
• 952423-55-1 C₁₇H₂₁NO₃ 
• 1227271-48-8 C₂₂H₂₃NO₄ 
• 1254104-38-5 3,3-difluoro-8-azabicyclo[3,2,1]octan-8-carboxylic acid benzyl ester 
• 1073923-19-9 benzyl 8-azaspiro[bicyclo[3.2.1]octane-3,2'-oxirane]-8-carboxylate 
• 951743-84-3 3-(1,5-Bis(4-methoxyphenyl)-1H-pyrazol-3-yl)-8-(N-hydroxy-N-methylcarbamoyl)-8-azabicyclo[3.2.1]octane 
• 951745-28-1 3-(1,5-bis(4-methoxyphenyl)-1H-pyrazol-3-yl)-8-azabicyclo[3.2.1]octane 
• 286947-16-8 3-tert-butoxycarbonyl-3,9-diazabicyclo-[4.2.1]-nonane 
• 1266350-22-4 benzyl 3-(1-formamido-2-ethoxy-2-oxoethylidene)-8-azabicyclo[3.2.1]-octane-8-carboxylate 

Relevant academic research and scientific papers

CHROMEN-4-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE

The present invention provides novel compounds having the general formula (I) wherein R1 to R6, and m are as described herein, compositions including the compounds and methods of using the compounds.

CYCLIC AMINE DERIVATIVE AND MEDICINAL USE THEREOF

PROBLEM TO BE SOLVED: To provide a novel compound having RORγ antagonist activity, and provide a therapeutic or preventive agent of autoimmune disease and allergic disease based on RORγ function inhibitory action through RORγ antagonist activity. SOLUTION

AN IMPROVED PROCESS FOR THE SYNTHESIS OF ALKYL/ARALKYL (2S)-2-(TERT-BUTOXYCARBONYL)-AMINO-2-[-8-AZABICYCLO[3.2.1]OCT-3-YL]-EXO-ACETATE AND ANALOGS THEREOF: KEY INTERMEDIATES FOR THE PREPARATION OF DPPIV INHIBITORS

An improved process for the synthesis of intermediates like Alkyl/Aralkyl (2S)-2-(tert-butoxycarbonyl)-amino-2-[-8-azabicyclo[3.2.1]oct-3-yl]-exo-acetate and analogs thereof which are useful in the synthesis of Dipeptidyl peptidase-IV (DPPIV) inhibitors.

HETEROARYLTHIOMETHYL PYRIDINE DERIVATIVE

The present invention relates to a compound represented by a formula (I): wherein X is a group represented by or the like; Y is a group represented by or the like; and Ar1 is a group represented by or a pharmaceutically acceptable salt thereof.

A scalable synthesis of an azabicyclooctanyl derivative, a novel DPP-4 inhibitor

(Chemical Equation Presented) A practical synthetic strategy to a chiral azabicycclooctanyl derivative (1), a potent DPP-4 inhibitor, starting from a commercially available nortropine is described. The stereogenic center of 1 was established employing a modified protocol of Ellman's diastereoselective addition of a benzylic nucleophile to tert-butanesulfinimine. Other key steps include Corey-Chaykovsky reaction, Meinwald rearrangement, and CDMT-promoted amide bond formation involving a sterically hindered amine 2.

UREIDE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES

This invention relates to a pharmaceutical comprising, as an active ingredient, a ureide derivative represented by formula: or a pharmaceutically acceptable salt thereof. The ureide derivative or a pharmaceutically acceptable salt thereof according to the present invention is useful for relieving pain and treating or preventing neuropathic pain.

SPIRO CONDENSED PIPERIDNES AS MODULATORS OF MUSCARINIC RECEPTORS

The present invention relates to modulators of muscarnic receptors of formula (I). The present invention also provides impositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

MODULATORS OF MUSCARINIC RECEPTORS

The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

MODULATORS OF MUSCARINIC RECEPTORS

The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

1- (2H-PYRAZOL -3-YL) -3YL) {4-`1- (BENZOYL) -PIPERIDIN-4-YLMETHYL!-PHENYL}-UREA DERIVATIVES AND RELATED COMPOUNDS AS INHBITORS OF P38 KINASE AND/OR TNF INHIBITORS FOR THE TREATMENT OF IMFLAMMATIONS

The present invention provides compounds of Formula (I) Wherein ( ) is an optional ethylene bridge; R1 is alkyl, cycloalkyl, aryl or aryl substituted with one or more substituents selected from alkyl, alkoxy and amino, or R1 is pyridyl or pyridyl substitu