130754-17-5

Basic information

• Product Name: ethyl 2-fluoro-2-(4-fluorophenyl)acetate
• Synonyms: ethyl 2-fluoro-2-(4-fluorophenyl)acetate
• CAS NO: 130754-17-5
• Molecular Weight: 200.185
• Mol File: 130754-17-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: ethyl 2-fluoro-2-(4-fluorophenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-fluoro-2-(4-fluorophenyl)acetate(130754-17-5)
• EPA Substance Registry System: ethyl 2-fluoro-2-(4-fluorophenyl)acetate(130754-17-5)

Safety Data

• Hazardous Substances Data: 130754-17-5(Hazardous Substances Data)

Upstream product

• 587-88-2 ethyl 2-(4-fluorophenyl)acetate 
• 401-55-8 ethyl bromofluoroacetate 
• 33715-53-6 triethoxy(4-fluorophenyl)silane 
• 401-56-9 ethyl chlorofluoroacetate 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 1765-93-1 4-fluoroboronic acid 
• 101-97-3 Ethyl 2-phenylethanoate 

Relevant articles and documents

Nickel-Catalyzed Cross-Coupling of Ethyl Chlorofluoroacetate with Aryl Bromides

A combinatorial nickel-catalyzed monofluoroalkylation of aryl bromides with the industrial raw regent ethyl chlorofluoroacetate has been developed. The two key factors to successful conversion are the combination of nickel with readily available nitrogen and phosphine ligands and the using of a mixture of different solvents. Mechanistic investigations indicated a new zinc regent might generated in situ and be involved in the reaction process.

Nickel-catalyzed monofluoromethylation of aryl boronic acids

Aryl boronic acids can be monofluoromethylated under nickel catalysis. The utility of this method is demonstrated by the monofluoromethylation of a borylated and acyl-protected derivative of the statin drug ezetimibe. Mechanistic investigations indicate that a fluoromethyl radical is involved in the NiI/NiIII catalytic cycle.

Selective electrolytic fluorinations in 70% HF/30% pyridine

The selective fluorination of compounds containing benzylic hydrogen atoms was accomplished by electrolysis in a mixture of 70% HF and 30% pyridine (Olah's reagent) using a square wave alternating current (1.76-2.75 V, 0.02-0.05 Hz) and Pt electrodes. This method can be used in the laboratory to prepare conveniently gram-size quantities of monofluorinated products. An ion radical mechanism has been proposed.