130767-63-4

Upstream product

• 867278-07-7 isopropoxy-acetic acid 5-(6-benzoylamino-purin-9-yl)-2-{[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-mercapto-phosphoryloxymethyl}-tetrahydro-furan-3-yl ester 
• 51549-40-7 6-N-benzoyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxyadenosine 
• 133471-22-4 C₅₇H₇₀N₇O₁₂PSi₂ 
• 130767-62-3 C₅₄H₆₂N₇O₁₂PSi 
• 130767-65-6 C₅₄H₆₂N₇O₁₂PSSi 
• 133471-22-4 C₅₇H₇₀N₇O₁₂PSi₂ 

Downstream Products

• 130767-64-5 Thiophosphoric acid O-[(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl] ester O'-[(2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester 
• 867277-88-1 C₅₅H₅₃N₈O₁₄PS 

Relevant academic research and scientific papers

New approach to the synthesis of oligodeoxyribonucleotides modified with phosphorothioates of predetermined sense of P-chirality

Appropriately protected, diastereomerically pure dinucleoside phosphorothioates, obtained by the stereocontrolled oxathiaphospholane method, were S-alkylated with 2-nitrobenzyl bromide and then converted into their 3′-O-phosphoramidites. The corresponding S-protected dinucleotide building blocks were successfully used for the synthesis of oligonucleotides containing P-stereodefined phosphorothioate bonds at preselected positions.