867278-07-7Relevant academic research and scientific papers
New approach to the synthesis of oligodeoxyribonucleotides modified with phosphorothioates of predetermined sense of P-chirality
Nawrot, Barbara,R?bowska, Beata,Cie?lińska, Katarzyna,Stec, Wojciech J.
, p. 6641 - 6644 (2007/10/03)
Appropriately protected, diastereomerically pure dinucleoside phosphorothioates, obtained by the stereocontrolled oxathiaphospholane method, were S-alkylated with 2-nitrobenzyl bromide and then converted into their 3′-O-phosphoramidites. The corresponding S-protected dinucleotide building blocks were successfully used for the synthesis of oligonucleotides containing P-stereodefined phosphorothioate bonds at preselected positions.
