130788-41-9

Upstream product

• 130788-40-8 2-(3-methoxyphenyl)propanal 
• 78-94-4 methyl vinyl ketone 
• 120125-63-5 cis/trans-ethyl 2-(3-methoxyphenyl)-2-methyl-1-oxirane-1-carboxylate 
• 130788-39-5 2-hydroxy-3-(3-methoxyphenyl)-3-butenoic acid 
• 135657-28-2 ethyl 2-hydroxy-3-(3-methoxyphenyl)-3-butenoate 
• 586-37-8 1-(3-Methoxyphenyl)ethanone 
• 5323-87-5 3-Ethoxycyclohex-2-en-1-one 
• 62952-33-4 3-ethoxy-6-methylcyclohex-2-en-1-one 
• 504-02-9 1,3-cylohexanedione 
• 191725-61-8 1-methoxy-2-(3'-methoxyphenyl)propene 

Downstream Products

• 130788-30-6 4-(3-methoxyphenyl)-4-methyl-cyclohexanone 
• 130788-33-9 (+)-E-trans-2(R),4(S)-4-(3-methoxyphenyl)-2,4-dimethylcyclohexanone oxime 
• 130788-34-0 (-)-trans-5(S),7(R)-hexahydro-5-(3-methoxyphenyl)-5,7-dimethyl-2H-azepine-2-one 
• 135657-30-6 (-)-trans-5(S),7(R)-hexahydro-5-(3-methoxyphenyl)-1,5,7-trimethyl-2-azepinone 
• 130788-31-7 2(S)-2-methoxymethyl-N-<4'-(3-methoxyphenyl)-4'-methylcyclohexylidene>-1-pyrrolidinamine 
• 130788-35-1 (+)-5(S),7(R)-5-(3-methoxyphenyl)-5-methyl-7-(N-methyltrifluoroacetamido)octan-2-one 
• 130855-86-6 (+)-cis-2(R),4(R)-4-(3-methoxyphenyl)-2,4-dimethylcyclohexanone 
• 130788-32-8 (+)-trans-2(R),4(S)-4-(3-methoxyphenyl)-2,4-dimethylcyclohexanone 
• 130788-29-3 ((S)-2-Methoxymethyl-pyrrolidin-1-yl)-[(R)-4-(3-methoxy-phenyl)-2,4-dimethyl-cyclohex-(Z)-ylidene]-amine 
• 135684-72-9 (+)-cis-5(R),7(R)-hexahydro-5-(3-methoxyphenyl)-5,7-dimethyl-2H-azepine-2-one 
• 130788-33-9 (+)-E-cis-2(R),4(R)-4-(3-methoxyphenyl)-2,4-dimethylcyclohexanone oxime 

Relevant academic research and scientific papers

Nickel-Catalyzed Desymmetric Hydrogenation of Cyclohexadienones: An Efficient Approach to All-Carbon Quaternary Stereocenters

Nickel-catalyzed desymmetric hydrogenation has been achieved. With the Ni(OTf)2/(S,S)-Ph-BPE system, a series of ?,?-disubstituted cyclohexadienones were transformed to the corresponding cyclohexenones with a chiral all-carbon quaternary center at the γposition in high yields (92-98%) and excellent enantioselectivities (92%-99% ee). This catalytic system can also tolerate the desymmetric reaction of spirocarbocyclic cyclohexadienones to produce the corresponding cyclohexenones bearing a chiral spiro quaternary carbon with high yields (94%-98%) and ee values (96%-99% ee). Furthermore, this methodology provides an efficient and concise synthetic route to the intermediate of natural products cannabispirenones A and B.

Palladium-Catalyzed α-Arylation of Vinylogous Esters for the Synthesis of γ,γ-Disubstituted Cyclohexenones

A palladium-catalyzed α-arylation of cyclic vinylogous esters to form products that are converted in one step to γ-alkyl-γ-aryl-substituted cyclohexenones is reported. This Pd-catalyzed reaction proceeds at room temperature, is generally high-yielding, and uses an amount of a commercially available catalyst as low as 0.25 mol %. The scope of aryl bromides is particularly broad, and alkenyl bromides can also be used. This two-step protocol, comprising α-arylation and reductive transposition, can be performed in one pot and is applicable to gram-scale synthesis.

Chiral synthesis of 6,7-benzomorphans: Synthesis of ( -)1(S),2(S),4(R),6(R)-1,2,3,4,5,6-hexahydro-2,6-methano-8-methoxy -1,3,4,6-tetramethyl-3-benzazocine through the chromium hexacarbonyl mediated cyclisation of 1(S),1 ′(R)-1,2-dihydro-7-methoxy-1,4-dimethyl -1 (N-methy-N-trifluoroacetamido-1′-methylethan-2′-yl)naphthalene

(-)1(S),2(S),4(R),6(R)-1,2,3,4,5,6-Hexahydro-2,6-methano-8-methoxy- 1,3,4,6-tetramethyl-3-benzazocine has been synthesised in 86 % enandomeric excess from the α-(v6-chromium tricarbonyl) complex of 1 (S), 1′(R)-1,2-dihydro-7-methoxy-1,4-dimethyl-1-(N-methyl-N-trifluoroacetamido- 1′-methylethan-2/-yl)naphthalene. A precursor of this compound is 2(R),4(,S)-4-(3-methoxyphenyl)-2,4-dimethylcyclohexanone which was obtained through an Enders' type C-methylation reaction of 4-(3-methoxyphenyl)4-methylcyclohexanone using SAMP as the reagent.