1307886-98-1Relevant articles and documents
Chiral schiff bases synthesized from terpenes of pinane series in asymmetric metall complex oxidation of sulfi des
Il'ina,Koneva,Korchagina,Sal'Nikov,Genaev,Volcho,Salakhutdinov
experimental part, p. 214 - 220 (2012/06/16)
The absolute confi guration of α-hydroxyaldehyde obtained from verbenol epoxide in the presence of clay was determined. Two new Schiff bases were synthesized from the aldehyde obtained. The compounds can be used as ligands in the asymmetric vanadium-catalyzed oxidation of sulfi des to sulfoxides. The structure of initial sulfi des signifi cantly affects the value of the enantiomeric excess in the obtained sulfoxides: the highest enantiomeric excess is observed in the oxidation of thioanisole. Pleiades Publishing, Ltd., 2012.
Highly potent activity of (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3- ene-1,2-diol in animal models of parkinson's disease
Ardashov, Oleg V.,Pavlova, Alla V.,Il'ina, Irina V.,Morozova, Ekaterina A.,Korchagina, Dina V.,Karpova, Elena V.,Volcho, Konstantin P.,Tolstikova, Tat'yana G.,Salakhutdinov, Nariman F.
experimental part, p. 3866 - 3874 (2011/08/07)
(1R,2R,6S)-3-Methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol 1 possesses potent antiparkinsonian activity in both MPTP and haloperidol animal models. The use of compound 1 resulted in nearly full recovery of the locomotor and exploratory activities and was as effective as the comparator agent (levodopa). All eight stereoisomers of compound 1 have been synthesized and the influence of the absolute configuration on the antiparkinsonian activity of compound 1 was shown.
