924265-29-2Relevant academic research and scientific papers
Synthesis and analgesic activity of stereoisomers of 2-(3(4)-hydroxy-4(3)-methoxyphenyl)-4,7-dimethyl-3,4,4a,5,8,8a-hexahydro-2H-chromene-4,8-diols
Pavlova, Alla,Mikhalchenko, Oksana,Rogachev, Artem,Il'Ina, Irina,Korchagina, Dina,Gatilov, Yuriy,Tolstikova, Tat'Yana,Volcho, Konstantin,Salakhutdinov, Nariman
, p. 3821 - 3830 (2015/10/06)
2-(3(4)-Hydroxy-4(3)-methoxyphenyl)-4,7-dimethyl-3,4,4a,5,8,8a-hexahydro-2H-chromene-4,8-diols were found recently to possess high analgesic activity and low acute toxicity. Stereoisomers of these compounds with high optical purity were synthesized from (+)- and (-)-α-pinenes for the first time in this work. The structure of (4S)-4b isomer was confirmed by the XRD data. Studies of analgesic activity of the resulting products demonstrated that neither the absolute configuration nor cis- or trans-arrangement of vicinal oxygen atoms plays a significant role in manifestation of analgesic effect by these isomers, while only (4S)-4b isomer, but not (4R)-4b demonstrated the analgesic effect.
Antiviral activity of 3-methyl-6-(prop-l-en-2-yl)cyclohex-3-ene-l,2-diol and its derivatives against influenza A(HlNl)2009 virus
Ardashov, Oleg V.,Zarubaev, Vladimir V.,Shtro, Anna A.,Korchagina, Dina V.,Volcho, Konstantin P.,Salakhutdinov, Nariman F.,Kiselev, Oleg I.
, p. 375 - 380 (2012/06/01)
A number of new derivatives of monoterpenoid with a para-menthane framework 3-methyl-6-(prop-1-en-2- yl)cyclohex-3-ene-1,2-diol (-)-3 were synthesized. The antiviral activity of (-)-3 and its derivatives against the pandemic influenza virus A/California/07/09 (H1N1)v was studied in vitro. Compound (-)-3 was found to be active against this virus (selectivity index 7.5); for mononicotinate (+)-6 the selectivity index was 17. The absolute configuration of compound 6 was shown to be critical for its antiviral activity.
